Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0177 | 0.0599 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0177 | 0.0177 |
Plasmodium falciparum | protein kinase 5 | 0.0097 | 0.2694 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.2949 | 0.2949 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1216 | 0.4125 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0177 | 0.0177 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.2694 | 0.9137 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1091 | 0.1091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1091 | 0.1091 |
Giardia lamblia | Glycogen phosphorylase | 0.0105 | 0.2949 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0097 | 0.2694 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1091 | 0.1091 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0097 | 0.2694 | 0.2694 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0097 | 0.2694 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.2949 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0177 | 0.0177 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0097 | 0.2694 | 0.2694 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0177 | 0.0599 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1091 | 0.37 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1091 | 0.37 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0177 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.2949 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0097 | 0.2694 | 0.2694 |
Echinococcus multilocularis | geminin | 0.0332 | 1 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0105 | 0.2949 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0045 | 0.1102 | 0.1102 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0097 | 0.2694 | 0.2694 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0097 | 0.2694 | 0.2694 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.2694 | 0.2694 |
Brugia malayi | cell division control protein 2 homolog | 0.0097 | 0.2694 | 0.9137 |
Plasmodium vivax | protein kinase Crk2 | 0.0097 | 0.2694 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0045 | 0.1102 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0105 | 0.2949 | 0.2949 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.2949 | 0.2949 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.2949 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0105 | 0.2949 | 0.2949 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.2949 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0097 | 0.2694 | 0.2694 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0105 | 0.2949 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1091 | 0.1091 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.2949 | 0.2949 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0097 | 0.2694 | 0.2694 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0097 | 0.2694 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1216 | 0.4125 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.2949 | 0.2949 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1216 | 0.4125 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0097 | 0.2694 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1091 | 0.1091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1091 | 0.1091 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0097 | 0.2694 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0735 | 0.2493 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0045 | 0.1102 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.2694 | 0.2694 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0097 | 0.2694 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0097 | 0.2694 | 0.9137 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0105 | 0.2949 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0097 | 0.2694 | 0.8622 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0735 | 0.2493 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.2949 | 0.2949 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0177 | 0.0177 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0097 | 0.2694 | 0.8622 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0177 | 0.0599 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.2949 | 0.2949 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0097 | 0.2694 | 0.9137 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2662 | 0.9028 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0097 | 0.2694 | 0.9137 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0735 | 0.0735 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0097 | 0.2694 | 0.2694 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0097 | 0.2694 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1216 | 0.4125 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0105 | 0.2949 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0097 | 0.2694 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0177 | 0.0599 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0177 | 0.0177 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1091 | 0.1091 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0177 | 0.0177 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0177 | 0.0177 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0097 | 0.2694 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0177 | 0.0177 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.013 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.