Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0778 | 0.152 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0778 | 0.152 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0111 | 0.4026 | 0.3906 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0111 | 0.4026 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0051 | 0.0196 | 0.0196 |
Schistosoma mansoni | nuclear hormone receptor | 0.0051 | 0.0196 | 0.0196 |
Schistosoma mansoni | thyroid hormone receptor | 0.0051 | 0.0196 | 0.0196 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0778 | 0.152 |
Schistosoma mansoni | thyroid hormone receptor | 0.0051 | 0.0196 | 0.0196 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0111 | 0.4026 | 0.3906 |
Giardia lamblia | Glycogen phosphorylase | 0.0111 | 0.4026 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0111 | 0.4026 | 0.4026 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0111 | 0.4026 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0048 | 0 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0048 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0051 | 0.0196 | 0.0196 |
Echinococcus granulosus | glycogen phosphorylase | 0.0111 | 0.4026 | 0.3906 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0111 | 0.4026 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0111 | 0.4026 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0111 | 0.4026 | 0.4026 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0111 | 0.4026 | 0.3906 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0778 | 0.152 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0111 | 0.4026 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0111 | 0.4026 | 0.3906 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0051 | 0.0196 | 0.0196 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0111 | 0.4026 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0111 | 0.4026 | 0.3906 |
Schistosoma mansoni | coup transcription factor | 0.0051 | 0.0196 | 0.0196 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0051 | 0.0196 | 0.0196 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0111 | 0.4026 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0051 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0111 | 0.4026 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0051 | 0.0196 | 0.0196 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0051 | 0.0196 | 0.0196 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0051 | 0.0196 | 0.0196 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0051 | 0.0196 | 0.0196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.