Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0107471 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0107471 | 1 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0046686 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0107471 | 1 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0046686 | 0 | 0.5 |
Toxoplasma gondii | cathepsin B | 0.0046686 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0046686 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0107471 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0046686 | 0 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0107471 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0107471 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0046686 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0107471 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0107471 | 1 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0107471 | 1 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0046686 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0107471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107471 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.01 uM | Antiparasitic activity against trypomastigote form of drug-sensitive Trypanosoma brucei assessed as inhibition of parasite growth after 4 days using alamar blue/resazurin staining by fluorimetric method | ChEMBL. | 22197138 |
IC50 (functional) | = 8.75 uM | Antiparasitic activity against nifurtimox-sensitive amastigotes of Trypanosoma cruzi Tulahuen expressing LacZ gene infected in human MRC5 cells using chlorophenolred b-Dgalacto-pyranoside as substrate by colorimetric method | ChEMBL. | 22197138 |
IC50 (ADMET) | = 12.44 uM | Cytotoxicity against human MRC5 cells after 4 to 7 days using alamar blue/resazurin staining by fluorescence assay | ChEMBL. | 22197138 |
IC50 (functional) | = 18.61 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GHA infected in human erythrocytes assessed as parasite growth after 72 hrs by malstat reagent based spectrophotometric method | ChEMBL. | 22197138 |
IC50 (functional) | = 32 uM | Antiparasitic activity against amastigotes of Leishmania infantum infected in mouse peritoneal macrophages after 5 days using giemsa staining by microscopic analysis | ChEMBL. | 22197138 |
IC50 (functional) | = 37.33 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GHA infected in human erythrocytes assessed as parasite growth after 72 hrs by malstat reagent based spectrophotometric method | ChEMBL. | 22197138 |
IC50 (ADMET) | = 64 uM | Cytotoxicity against human MRC5 cells after 4 to 7 days using alamar blue/resazurin staining by fluorescence assay | ChEMBL. | 22197138 |
IC50 (functional) | = 64 uM | Antiparasitic activity against nifurtimox-sensitive amastigotes of Trypanosoma cruzi Tulahuen expressing LacZ gene infected in human MRC5 cells using chlorophenolred b-Dgalacto-pyranoside as substrate by colorimetric method | ChEMBL. | 22197138 |
IC50 (functional) | = 64 uM | Antiparasitic activity against amastigotes of Leishmania infantum infected in mouse peritoneal macrophages after 5 days using giemsa staining by microscopic analysis | ChEMBL. | 22197138 |
IC50 (functional) | = 64 uM | Antiparasitic activity against trypomastigote form of drug-sensitive Trypanosoma brucei assessed as inhibition of parasite growth after 4 days using alamar blue/resazurin staining by fluorimetric method | ChEMBL. | 22197138 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22197138 | |
Trypanosoma cruzi | ChEMBL23 | 22197138 | |
Trypanosoma brucei | ChEMBL23 | 22197138 | |
Homo sapiens | ChEMBL23 | 22197138 | |
Trypanosoma brucei gambiense | 22197138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.