Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated potassium channel | 0.0063 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0783 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0063 | 0.0271 | 0.0271 |
Entamoeba histolytica | histone deacetylase, putative | 0.0783 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0063 | 0.0271 | 0.0271 |
Plasmodium falciparum | histone deacetylase 1 | 0.0783 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0394 | 0.4743 | 0.4743 |
Schistosoma mansoni | histone deacetylase | 0.0783 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 0.0291 | 0.0291 |
Echinococcus granulosus | histone deacetylase 7 | 0.0394 | 0.4743 | 0.4743 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0264 | 0.2977 | 0.2977 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0783 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0783 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0239 | 0.2641 | 0.2641 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0264 | 0.2977 | 0.2977 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1278 | 0.1278 |
Brugia malayi | Histone deacetylase 1 | 0.0783 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0783 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0783 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0783 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0264 | 0.2977 | 0.2977 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0394 | 0.4743 | 0.4743 |
Echinococcus granulosus | histone deacetylase 6 | 0.0402 | 0.484 | 0.484 |
Brugia malayi | Histone deacetylase family protein | 0.0394 | 0.4743 | 0.4743 |
Loa Loa (eye worm) | histone deacetylase | 0.0394 | 0.4743 | 0.4743 |
Giardia lamblia | Histone deacetylase | 0.0783 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0394 | 0.4743 | 0.4743 |
Plasmodium vivax | histone deacetylase, putative | 0.0394 | 0.4743 | 0.2514 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0394 | 0.4743 | 0.2514 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0219 | 0.2369 | 0.2369 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0783 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0783 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0394 | 0.4743 | 0.2514 |
Echinococcus granulosus | histone deacetylase 3 | 0.0783 | 1 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0264 | 0.2977 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0783 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0394 | 0.4743 | 0.2514 |
Trypanosoma brucei | histone deacetylase 4 | 0.0394 | 0.4743 | 0.2514 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0394 | 0.4743 | 0.4743 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1181 | 0.1181 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0063 | 0.0271 | 0.0271 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0783 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0063 | 0.0271 | 0.0271 |
Echinococcus granulosus | histone deacetylase | 0.0394 | 0.4743 | 0.4743 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0219 | 0.2369 | 0.2369 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0783 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0065 | 0.0291 | 0.0291 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0239 | 0.2641 | 0.2641 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0063 | 0.0271 | 0.0271 |
Echinococcus granulosus | histone deacetylase 6 | 0.0394 | 0.4743 | 0.4743 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0783 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0783 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0219 | 0.2369 | 0.2369 |
Echinococcus multilocularis | histone deacetylase | 0.0394 | 0.4743 | 0.4743 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0264 | 0.2977 | 0.2977 |
Trypanosoma brucei | histone deacetylase 3 | 0.0394 | 0.4743 | 0.2514 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0402 | 0.484 | 0.484 |
Echinococcus granulosus | histone deacetylase 6 | 0.0394 | 0.4743 | 0.4743 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0783 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0783 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0783 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0783 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0783 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0394 | 0.4743 | 0.2514 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0264 | 0.2977 | 0.2977 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0394 | 0.4743 | 0.2514 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0783 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0394 | 0.4743 | 0.4743 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0783 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0394 | 0.4743 | 0.4743 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0394 | 0.4743 | 0.2514 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0204 | 0.2175 | 0.2175 |
Leishmania major | histone deacetylase, putative | 0.0783 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2977 | 0.2977 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0271 | 0.0271 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0783 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1979 | 0.1979 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0783 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0063 | 0.0271 | 0.0271 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0402 | 0.484 | 0.484 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0783 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0394 | 0.4743 | 0.4743 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0204 | 0.2175 | 0.2175 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0219 | 0.2369 | 0.2369 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0783 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0264 | 0.2977 | 0.2977 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human GSTM1 using GSH as substrate after 3 mins by spectrophotometry | ChEMBL. | 22085405 | |
IC50 (functional) | > 50 uM | Cytotoxicity against human HL60 cells | ChEMBL. | 23102892 |
IC50 (binding) | > 100 uM | Inhibition of human GSTA2 using GSH as substrate after 3 mins by spectrophotometry | ChEMBL. | 22085405 |
IC50 (binding) | > 100 uM | Inhibition of human GSTP1-1 using GSH as substrate after 3 mins by spectrophotometry | ChEMBL. | 22085405 |
Inhibition (binding) | = 12 % | Inhibition of human GSTP1-1 using GSH as substrate at 100 uM after 3 mins by spectrophotometry | ChEMBL. | 22085405 |
Inhibition (binding) | = 16 % | Inhibition of human GSTA2 using GSH as substrate at 100 uM after 3 mins by spectrophotometry | ChEMBL. | 22085405 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.