TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 677.872 | Formula: C35H59N5O8
H donors: 7 H acceptors: 7 LogP: 2.89 Rotable bonds: 27
Rule of 5 violations (Lipinski): 3
SMILES: CCCCC(C(=O)NC(C(CC(=O)NC(C(=O)NC(C(CC(=O)OC)O)CC(C)C)C)O)CC(C)C)NC(=O)C(Cc1ccccc1)N
InChi: 1S/C35H59N5O8/c1-8-9-15-26(38-34(46)25(36)18-24-13-11-10-12-14-24)35(47)40-27(16-21(2)3)29(41)19-31(43)37-23(6)33(45)39-28(17-22(4)5)30(42)20-32(44)48-7/h10-14,21-23,25-30,41-42H,8-9,15-20,36H2,1-7H3,(H,37,43)(H,38,46)(H,39,45)(H,40,47)
InChiKey: WZHKLEDIWDFXHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	plasmepsin IV	0.0059	0.0668	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0743	0.0743
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Trypanosoma brucei	dynamin-1-like protein	0.0021	0.0131	0.0078
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0509	0.0521
Trichomonas vaginalis	glutaminase, putative	0.0547	0.7535	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0059	0.0668	0.0725
Brugia malayi	RNA binding protein	0.0064	0.0743	0.0826
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0509	0.0521
Brugia malayi	Dynamin	0.0022	0.0153	0.0138
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0392	0.535	0.535
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0743	0.0743
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0064	0.0035
Loa Loa (eye worm)	Poly(ADP-ribose) glycohydrolase	0.0624	0.8611	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0064	0.0064
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0668	0.0738
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0059	0.0668	0.0668
Plasmodium falciparum	plasmepsin I	0.0059	0.0668	1
Plasmodium falciparum	dynamin-like protein	0.0021	0.0131	0.1519
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0048	0.0509	0.0554
Entamoeba histolytica	poly(ADP-ribose) glycohydrolase, putative	0.0278	0.3746	0.4263
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0014	0.0035	0.0004
Echinococcus multilocularis	dynamin	0.0021	0.0131	0.0131
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0344	0.4679	0.5415
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0509	0.0521
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0048	0.0509	0.0509
Entamoeba histolytica	poly(ADP-ribose) glycohydrolase, putative	0.0624	0.8611	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.2283	0.2283
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0743	0.0826
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0048	0.0509	0.0509
Brugia malayi	Dynamin central region family protein	0.0021	0.0131	0.0112
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0048	0.0509	0.0554
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0344	0.4679	0.5415
Brugia malayi	Poly	0.0624	0.8611	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.2283	0.2283
Loa Loa (eye worm)	hypothetical protein	0.0392	0.535	0.6197
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0743	0.0826
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Echinococcus granulosus	polyADP ribose glycohydrolase	0.0624	0.8611	0.8611
Schistosoma mansoni	microtubule-associated protein tau	0.0723	1	1
Trypanosoma brucei	poly(ADP-ribose) glycohydrolase, putative	0.0624	0.8611	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0059	0.0668	0.0668
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0199	0.0157
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0064	0.0039
Entamoeba histolytica	hypothetical protein	0.0624	0.8611	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0064	0.0035
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0048	0.0509	0.0509
Brugia malayi	glutaminase DH11.1	0.0547	0.7535	0.8745
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0048	0.0509	0.0554
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0064	0.0039
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.7498
Toxoplasma gondii	aspartyl protease	0.0014	0.0035	0.0004
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0199	0.259
Brugia malayi	hypothetical protein	0.0017	0.0071	0.0042
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0048	0.0509	0.0509
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Plasmodium vivax	dynamin protein, putative	0.0021	0.0131	0.1519
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0048	0.0509	0.0511
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0048	0.0509	0.0554
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0048	0.0509	0.0509
Schistosoma mansoni	memapsin-2 (A01 family)	0.0014	0.0035	0.0035
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0344	0.4679	0.4679
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0509	0.0521
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0064	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0048	0.0509	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0509	0.0554
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0048	0.0509	0.0521
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Plasmodium vivax	plasmepsin IV, putative	0.0059	0.0668	1
Schistosoma mansoni	dynamin	0.0022	0.0153	0.0153
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0048	0.0509	0.0509
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0392	0.535	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0048	0.0509	0.0509
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0048	0.0509	0.0509
Toxoplasma gondii	dynamin-related protein DRPB	0.0021	0.0131	0.0116
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Leishmania major	hypothetical protein, conserved	0.0026	0.0199	0.3019
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Giardia lamblia	hypothetical protein	0.0048	0.0509	0.0725
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0064	0.0064
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0048	0.0509	0.0511
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0199	0.0191
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0064	0.0064
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0048	0.0509	0.0521
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.7498
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0048	0.0509	0.0521
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Trypanosoma brucei	RNA helicase, putative	0.0136	0.1753	0.1976
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.7498
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0048	0.0509	0.0521
Loa Loa (eye worm)	glutaminase 2	0.0547	0.7535	0.8745
Leishmania major	hypothetical protein, conserved	0.0048	0.0509	1
Loa Loa (eye worm)	glutaminase	0.0547	0.7535	0.8745
Brugia malayi	hypothetical protein	0.0026	0.0199	0.0191
Echinococcus multilocularis	dynamin 1	0.0022	0.0153	0.0153
Toxoplasma gondii	poly(ADP-ribose) glycohydrolase	0.0624	0.8611	1
Echinococcus multilocularis	dynamin 1 protein	0.0021	0.0131	0.0131
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0059	0.0668	0.0742
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0521
Plasmodium falciparum	dynamin-like protein	0.0021	0.0131	0.1519
Toxoplasma gondii	poly(ADP-ribose) glycohydrolase	0.0278	0.3746	0.433
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0064	0.0468
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0509	0.0554
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0059	0.0668	0.0668
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0064	0.0468
Brugia malayi	TAR-binding protein	0.0064	0.0743	0.0826
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0048	0.0509	0.0509
Loa Loa (eye worm)	PDE1B protein	0.0048	0.0509	0.0554
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Loa Loa (eye worm)	DRP-1 protein	0.0021	0.0131	0.0112
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0743	0.0743
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0392	0.535	0.6199
Toxoplasma gondii	aspartyl protease ASP3	0.0014	0.0035	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0509	0.0521
Echinococcus multilocularis	microtubule associated protein 2	0.0723	1	1
Echinococcus granulosus	dynamin	0.0021	0.0131	0.0131
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0392	0.535	0.535
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0048	0.0509	0.0511
Trypanosoma cruzi	hypothetical protein, conserved	0.0048	0.0509	0.0521
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0048	0.0509	0.0521
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Brugia malayi	Dynamin	0.0022	0.0153	0.0138
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0064	0.0064
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0048	0.0509	0.0509
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0064	0.0035
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0048	0.0509	0.0554
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0199	0.0157
Schistosoma mansoni	dynamin	0.0021	0.0131	0.0131
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Toxoplasma gondii	dynamin-related protein DRPA	0.0021	0.0131	0.0116
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0048	0.0509	0.0509
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0743	0.0826
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0048	0.0509	0.7498
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.7498
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0048	0.0509	0.0509
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0059	0.0668	0.0738
Toxoplasma gondii	aspartyl protease ASP1	0.0059	0.0668	0.0742
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.7498
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0509	0.0511
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0153	0.0138
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0509	0.0511
Echinococcus granulosus	dynamin 1 protein	0.0021	0.0131	0.0131
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0743	0.0743
Schistosoma mansoni	dynamin	0.0022	0.0153	0.0153
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0048	0.0509	0.0521
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0048	0.0509	0.0521
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0392	0.535	0.535
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0048	0.0509	0.0521
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Echinococcus granulosus	dynamin 1	0.0022	0.0153	0.0153
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0048	0.0509	0.0509
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0048	0.0509	0.7498
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0392	0.535	0.535
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0743	0.0743
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0048	0.0509	0.0521
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0199	0.0157
Trypanosoma cruzi	poly(ADP-ribose) glycohydrolase, putative	0.0624	0.8611	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0064	0.0064
Mycobacterium ulcerans	glutaminase	0.0547	0.7535	0.5
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Plasmodium vivax	phosphodiesterase gamma, putative	0.0048	0.0509	0.7498
Echinococcus multilocularis	poly(ADP ribose) glycohydrolase	0.0624	0.8611	0.8611
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Onchocerca volvulus		0.0014	0.0035	0.5
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0064	0.0064
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0048	0.0509	0.0521
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Schistosoma mansoni	hypothetical protein	0.0136	0.1753	0.1753
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0048	0.0509	0.0554
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0048	0.0509	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Schistosoma mansoni	poly(ADP-ribose) glycohydrolase	0.0624	0.8611	0.8611
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0048	0.0509	0.0509
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0743	0.0826
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Entamoeba histolytica	hypothetical protein	0.0278	0.3746	0.4263
Schistosoma mansoni	glutaminase	0.0547	0.7535	0.7535
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0392	0.535	0.535
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0048	0.0509	0.0509
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0048	0.0509	0.7498
Trypanosoma cruzi	poly(ADP-ribose) glycohydrolase, putative	0.0624	0.8611	1
Plasmodium falciparum	plasmepsin VI	0.0059	0.0668	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0509	0.0511
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0048	0.0509	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0064	0.0064
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0048	0.0509	0.0509
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0199	0.0195
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0048	0.0509	0.0509
Plasmodium falciparum	plasmepsin II	0.0059	0.0668	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0048	0.0509	0.0554
Plasmodium falciparum	phosphodiesterase delta, putative	0.0048	0.0509	0.7498
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Plasmodium vivax	dynamin-like protein, putative	0.0021	0.0131	0.1519
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0048	0.0509	0.0509
Onchocerca volvulus		0.0014	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0509	0.0554
Plasmodium vivax	aspartyl proteinase, putative	0.0059	0.0668	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0048	0.0509	0.0509
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0035	0.0035
Giardia lamblia	Hypothetical protein	0.0048	0.0509	0.0725
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0743	0.0743
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0048	0.0509	0.0509
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0344	0.4679	0.4679
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0521
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0199	0.259
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0048	0.0509	0.0511
Trypanosoma cruzi	dynamin-1-like protein	0.0021	0.0131	0.0078
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0048	0.0509	0.0509
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Leishmania major	GTP-binding protein, putative	0.0021	0.0131	0.1495
Trypanosoma brucei	dynamin-1-like protein	0.0021	0.0131	0.0078
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0048	0.0509	0.0509
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0048	0.0509	0.0521
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0743	0.0743
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0199	0.259
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0048	0.0509	0.0511
Leishmania major	hypothetical protein, conserved	0.0048	0.0509	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0048	0.0509	0.0557
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0048	0.0509	0.0521

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.00000077 M	In vitro inhibitory activity against human plasma renin	ChEMBL.	3543358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 116836

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 15968