Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NADPH oxidase, EF-hand calcium binding domain 5 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome b-245, beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | NADPH oxidase 1 | Starlite/ChEMBL | References |
Homo sapiens | NADPH oxidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Onchocerca volvulus | Dual oxidase homolog | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Loa Loa (eye worm) | blistered cuticle protein 3 | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127219 | All targets in OG5_127219 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | NADPH oxidase, EF-hand calcium binding domain 5 | 737 aa | 730 aa | 25.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0151 | 0.3832 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0244 | 1 | 0.5 |
Leishmania major | ferric reductase, putative | 0.0151 | 0.3832 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0244 | 1 | 1 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0151 | 0.3832 | 0.5 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0151 | 0.3832 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 93 nM | Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Ki (functional) | = 217 nM | Antagonist activity at human NOX1 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Ki (functional) | = 510 nM | Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Ki (functional) | = 610 nM | Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | ChEMBL. | 22041175 |
Papp (ADMET) | = 1.4 10'-6 cm/s | Apparent permeability across human Caco2 cells at 10 uM after 2 hrs | ChEMBL. | 22041175 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.