Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase-activated protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Brugia malayi | map kinase activated protein kinase protein 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase-activated protein kinase 2 | 370 aa | 303 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.1096 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1096 | 0.5 | 0.5 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.1096 | 0.5 | 0.5 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.1096 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 11 nM | Inhibition of MK2 using Fluo-betaA-11A NeoMPS as substrate pre-incubated for 30 mins before substrate addition measured after 2 hrs by IMAP assay | ChEMBL. | 22119462 |
EC50 (functional) | = 0.2 uM | Inhibition of LPS-induced TNFalpha production in human PBMC pre-incubated for 30 mins prior to LPS-induction measured after 4 hrs by ELISA | ChEMBL. | 22119462 |
EC50 (binding) | = 0.61 uM | Inhibition of MK2-mediated HSP27 phosphorylation in LPS-stimulated human THP1 cells pre-incubated for 60 mins prior to LPS-induction measured after 60 mins by multi-spot assay | ChEMBL. | 22119462 |
EC50 (functional) | = 0.62 uM | Inhibition of LPS-induced TNFalpha production in human THP1 cells pre-incubated for 30 mins prior to LPS-induction measured after 4 hrs by ELISA | ChEMBL. | 22119462 |
PPB (ADMET) | = 98.7 % | Plasma protein binding in human | ChEMBL. | 22119462 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22119462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.