Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolylcarboxypeptidase (angiotensinase C) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | prolylcarboxypeptidase (angiotensinase C) | 496 aa | 414 aa | 24.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Alhambra homolog | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0112 | 0.408 | 0.408 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.012 | 0.468 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.0925 | 0.1976 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0925 | 0.1313 |
Echinococcus granulosus | jumonji domain containing protein | 0.0081 | 0.1721 | 0.1721 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.408 | 0.8718 |
Giardia lamblia | PHD finger protein 15 | 0.0058 | 0 | 0.5 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0112 | 0.408 | 0.5795 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.0925 | 0.0925 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0081 | 0.1721 | 0.1721 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.0925 | 0.0925 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.0112 | 0.408 | 0.408 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.314 | 0.6709 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.408 | 0.8718 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0112 | 0.408 | 0.408 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0925 | 0.1313 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0191 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0058 | 0 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0152 | 0.7041 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0058 | 0 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.408 | 0.8718 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 333 nM | Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate after 30 mins by fluorescence analysis | ChEMBL. | 22290078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.