Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.1303 | 1 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.1303 | 1 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.1303 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.1303 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.1303 | 1 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.1303 | 1 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.1303 | 1 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.1303 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Ability to inhibit seizures induced by electroshock in mice administered per orally; i = inactive | ChEMBL. | 2213838 |
ED50 (functional) | = 10 mg kg-1 | Ability to potentiate pentobarbital-induced sleep administered per orally | ChEMBL. | 2213838 |
ED50 (functional) | = 14.3 mg kg-1 | Ability to inhibit seizures induced by pentylenetetrazole in mice administered per orally | ChEMBL. | 2213838 |
ED50 (functional) | = 14.3 mg kg-1 | Ability to inhibit seizures induced by pentylenetetrazole in mice administered per orally | ChEMBL. | 2213838 |
LD50 (ADMET) | > 800 mg kg-1 | Acute toxicity of the compound administered per orally | ChEMBL. | 2213838 |
LD50 (ADMET) | > 800 mg kg-1 | Acute toxicity of the compound administered per orally | ChEMBL. | 2213838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.