Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0155 | 0.3222 | 0.5118 |
Schistosoma mansoni | DNA topoisomerase II | 0.0091 | 0.1354 | 0.4204 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0217 | 0.5004 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0091 | 0.1354 | 0.181 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0225 | 0.5239 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0225 | 0.5239 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0091 | 0.1354 | 0.5 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0389 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.3222 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0091 | 0.1354 | 0.2707 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0091 | 0.1354 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0091 | 0.1354 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0091 | 0.1354 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0389 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0217 | 0.5004 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0389 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0079 | 0.1001 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0091 | 0.1354 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0389 | 1 | 0.5 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0389 | 1 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0389 | 1 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0134 | 0.2602 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0225 | 0.5239 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0091 | 0.1354 | 0.2707 |
Echinococcus granulosus | geminin | 0.0155 | 0.3222 | 0.5118 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.3222 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0225 | 0.5239 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5004 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0225 | 0.5239 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0091 | 0.1354 | 0.2707 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0217 | 0.5004 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (ADMET) | > 30 ug ml-1 | Cytotoxicity against LPS-induced mouse RAW264.7 cells treated 2 hrs before LPS challenge measured after 20 hrs by MTT assay | ChEMBL. | 22153343 |
IC50 (functional) | = 4.5 ug ml-1 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated for 2 hrs before LPS challenge measured after 20 hrs by Griess method | ChEMBL. | 22153343 |
IC50 (ADMET) | = 4.5 ug ml-1 | Cytotoxicity against LPS-induced mouse RAW264.7 cells treated 2 hrs before LPS challenge measured after 20 hrs by MTT assay | ChEMBL. | 22153343 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 22153343 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.