Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.012 | 0.1531 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0514 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.012 | 0.1531 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.012 | 0.1531 | 0.3728 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.012 | 0.1531 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0514 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.024 | 0.4106 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0104 | 0.1184 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.012 | 0.1531 | 0.5789 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.012 | 0.1531 | 0.2348 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.024 | 0.4106 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0297 | 0.5336 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.2644 | 0.4323 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0514 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.2644 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0297 | 0.5336 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.012 | 0.1531 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0177 | 0.2753 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.2644 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.012 | 0.1531 | 0.3728 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0297 | 0.5336 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.4106 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.012 | 0.1531 | 0.3728 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0297 | 0.5336 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.024 | 0.4106 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.012 | 0.1531 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.2644 | 0.4323 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0514 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0297 | 0.5336 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0514 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0514 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 uM | Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate after 30 mins | ChEMBL. | 22901392 |
Inhibition (binding) | = 0 % | Inhibition of Pseudomonas aeruginosa beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) at 10 uM using CENTA as chromogenic substrate | ChEMBL. | 22115595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.