Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.3323 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3323 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3323 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.3323 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3323 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3323 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3323 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.3323 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3323 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3323 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3323 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3323 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23.5 uM | Inhibition of EGFR T790M/L858R mutant expressed using baculovirus expression system by ELISA | ChEMBL. | 22227214 |
IC50 (binding) | = 35.8 uM | Inhibition of wild-type EGFR expressed using baculovirus expression system by ELISA | ChEMBL. | 22227214 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human A549 cells over-expressing EGFR gene after 72 hrs by SRB assay | ChEMBL. | 22227214 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human A431 cells over-expressing EGFR gene after 72 hrs by SRB assay | ChEMBL. | 22227214 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human NCI-H1975 cells over-expressing EGFR mutant gene after 72 hrs by SRB assay | ChEMBL. | 22227214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.