Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.0395 | 0.1286 | 0.1286 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0359 | 0.1138 | 0.1478 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0204 | 0.0499 | 0.0499 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0395 | 0.1286 | 0.3753 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Echinococcus granulosus | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Echinococcus multilocularis | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Schistosoma mansoni | glycogen phosphorylase | 0.0913 | 0.3426 | 0.3426 |
Loa Loa (eye worm) | carboxylesterase | 0.0359 | 0.1138 | 0.1335 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Leishmania major | hypothetical protein, unknown function,protein, unknown function | 0.0476 | 0.1621 | 0.1901 |
Echinococcus granulosus | carboxylesterase 5A | 0.0359 | 0.1138 | 0.1478 |
Brugia malayi | carbohydrate phosphorylase | 0.0913 | 0.3426 | 0.4018 |
Toxoplasma gondii | dgat2l1-prov protein | 0.2148 | 0.8527 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0359 | 0.1138 | 0.1335 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.2148 | 0.8527 | 1 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4018 |
Echinococcus granulosus | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0222 | 0.057 | 0.0669 |
Echinococcus granulosus | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0913 | 0.3426 | 0.4447 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0395 | 0.1286 | 0.3753 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.195 | 0.7705 | 0.9037 |
Giardia lamblia | Glycogen phosphorylase | 0.0913 | 0.3426 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.2148 | 0.8527 | 0.8527 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.2148 | 0.8527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1138 | 0.1335 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0913 | 0.3426 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.195 | 0.7705 | 0.7705 |
Echinococcus multilocularis | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0913 | 0.3426 | 0.4447 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1138 | 0.1335 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Mycobacterium ulcerans | hypothetical protein | 0.0476 | 0.1621 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0395 | 0.1286 | 0.3753 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0359 | 0.1138 | 0.1138 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.195 | 0.7705 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Schistosoma mansoni | hypothetical protein | 0.0476 | 0.1621 | 0.1621 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0359 | 0.1138 | 0.1335 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0204 | 0.0499 | 0.0585 |
Onchocerca volvulus | 0.2148 | 0.8527 | 1 | |
Echinococcus multilocularis | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.195 | 0.7705 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0476 | 0.1621 | 0.1621 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0913 | 0.3426 | 0.3426 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0395 | 0.1286 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0913 | 0.3426 | 0.4018 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.195 | 0.7705 | 0.9037 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0476 | 0.1621 | 0.1621 |
Brugia malayi | Carboxylesterase family protein | 0.0359 | 0.1138 | 0.1335 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0204 | 0.0499 | 0.0585 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.057 | 0.057 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0456 | 0.1536 | 0.1536 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 94.1 uM | Inhibition of His6-tagged c-Src kinase domain using AEEEIYGEFEAKKKK as substrate pre-incubated for 10 mins before substrate addition measured after 30 mins by Transcreener ADP2 FI Assay | ChEMBL. | 22119472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.