Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.0913 | 0.3426 | 0.3426 |
Loa Loa (eye worm) | carboxylesterase | 0.0359 | 0.1138 | 0.1335 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Leishmania major | hypothetical protein, unknown function,protein, unknown function | 0.0476 | 0.1621 | 0.1901 |
Brugia malayi | carbohydrate phosphorylase | 0.0913 | 0.3426 | 0.4018 |
Echinococcus granulosus | carboxylesterase 5A | 0.0359 | 0.1138 | 0.1478 |
Schistosoma mansoni | glycogen phosphorylase | 0.0395 | 0.1286 | 0.1286 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0359 | 0.1138 | 0.1478 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0204 | 0.0499 | 0.0499 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0395 | 0.1286 | 0.3753 |
Echinococcus granulosus | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Echinococcus multilocularis | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0395 | 0.1286 | 0.3753 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0913 | 0.3426 | 0.4447 |
Echinococcus granulosus | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.195 | 0.7705 | 0.9037 |
Giardia lamblia | Glycogen phosphorylase | 0.0913 | 0.3426 | 1 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.2148 | 0.8527 | 0.8527 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.2148 | 0.8527 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0359 | 0.1138 | 0.1335 |
Toxoplasma gondii | dgat2l1-prov protein | 0.2148 | 0.8527 | 1 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.2148 | 0.8527 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4018 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.2148 | 0.8527 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Trypanosoma brucei | RNA helicase, putative | 0.0222 | 0.057 | 0.0669 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0476 | 0.1621 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0395 | 0.1286 | 0.3753 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0359 | 0.1138 | 0.1138 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0359 | 0.1138 | 0.1335 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.195 | 0.7705 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0476 | 0.1621 | 0.1621 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Onchocerca volvulus | 0.2148 | 0.8527 | 1 | |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0204 | 0.0499 | 0.0585 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0913 | 0.3426 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1138 | 0.1335 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.195 | 0.7705 | 0.7705 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0913 | 0.3426 | 0.4447 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0913 | 0.3426 | 0.4447 |
Echinococcus multilocularis | acetylcholinesterase | 0.0359 | 0.1138 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1138 | 0.1335 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0476 | 0.1621 | 0.1901 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.195 | 0.7705 | 0.9037 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0476 | 0.1621 | 0.1621 |
Brugia malayi | Carboxylesterase family protein | 0.0359 | 0.1138 | 0.1335 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0204 | 0.0499 | 0.0585 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.057 | 0.057 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0456 | 0.1536 | 0.1536 |
Schistosoma mansoni | diacylglycerol O-acyltransferase | 0.0476 | 0.1621 | 0.1621 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.195 | 0.7705 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0913 | 0.3426 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0395 | 0.1286 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0913 | 0.3426 | 0.3426 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0913 | 0.3426 | 0.4018 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0204 | 0.0499 | 0.0647 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 150 uM | Inhibition of His6-tagged c-Src kinase domain using AEEEIYGEFEAKKKK as substrate pre-incubated for 10 mins before substrate addition measured after 30 mins by Transcreener ADP2 FI Assay | ChEMBL. | 22119472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.