Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1003 | 0.0998 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.1246 | 0.1813 | 0.3111 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.3691 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.1094 | 0.1304 | 0.2238 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.2445 | 0.5827 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.3691 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.174 | 0.3468 | 0.5951 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.1246 | 0.1813 | 0.5229 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.174 | 0.3468 | 0.5951 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.174 | 0.3468 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.1246 | 0.1813 | 0.3111 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1003 | 0.0998 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | < 15 % | Agonist activity at human 5-HT6 serotonin receptor expressed in CHO-1 cells assessed as cAMP production relative to 5-hydroxytryptamine | ChEMBL. | 22290076 |
Kbapp (functional) | = 12 nM | Antagonist activity at human 5-HT6 serotonin receptor expressed in CHO-1 cells assessed as inhibition of 5-hydroxytryptamine-induced cAMP production | ChEMBL. | 22290076 |
Kbapp (functional) | = 15 nM | Antagonist activity at human 5-HT6 serotonin receptor expressed in CHO-1 cells assessed as inhibition of 5-hydroxytryptamine-induced cAMP production | ChEMBL. | 22290076 |
Ki (binding) | = 1.4 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 1.4 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 1.5 nM | Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay | ChEMBL. | 22290076 |
Ki (binding) | = 2.1 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 2.1 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 2.4 nM | Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay | ChEMBL. | 22290076 |
Ki (binding) | = 3.7 nM | Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay | ChEMBL. | 22290076 |
Ki (binding) | = 4.5 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 4.5 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
permeability (ADMET) | = 16.5 ucm/s | Permeability from apical to basolateral side of human Caco2 cells | ChEMBL. | 22290076 |
permeability (ADMET) | = 24.8 ucm/s | Permeability from apical to basolateral side of human Caco2 cells | ChEMBL. | 22290076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.