Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0537 | 0.0305 | 0.0305 |
Echinococcus granulosus | insulin receptor | 0.1169 | 0.0976 | 0.0976 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.1169 | 0.0976 | 0.0976 |
Schistosoma mansoni | tyrosine kinase | 0.0537 | 0.0305 | 0.0305 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.5751 | 0.5838 | 0.5838 |
Loa Loa (eye worm) | hypothetical protein | 0.1834 | 0.1681 | 0.1681 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0537 | 0.0305 | 0.0305 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0537 | 0.0305 | 0.0305 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.9673 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0537 | 0.0305 | 0.0305 |
Echinococcus multilocularis | insulin receptor | 0.1169 | 0.0976 | 0.0976 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0537 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.2102 | 0.1966 | 0.1966 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0537 | 0.0305 | 0.0305 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.9673 | 1 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.9673 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.9673 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.9673 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0537 | 0.0305 | 0.0305 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.1169 | 0.0976 | 0.0976 |
Brugia malayi | Protein kinase domain containing protein | 0.2102 | 0.1966 | 0.1966 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.1169 | 0.0976 | 0.0976 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.9673 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1169 | 0.0976 | 0.0976 |
Schistosoma mansoni | tyrosine kinase | 0.0518 | 0.0285 | 0.0285 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.3922 | 0.3898 | 0.3898 |
Brugia malayi | Protein kinase domain containing protein | 0.0651 | 0.0426 | 0.0426 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.9673 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0518 | 0.0285 | 0.0285 |
Schistosoma mansoni | tyrosine kinase | 0.1169 | 0.0976 | 0.0976 |
Schistosoma mansoni | tyrosine kinase | 0.1169 | 0.0976 | 0.0976 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0537 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.9673 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0518 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.0406 | 0.0406 |
Schistosoma mansoni | tyrosine kinase | 0.0537 | 0.0305 | 0.0305 |
Onchocerca volvulus | 0.9673 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 200 nM | Inhibitory concentration against recombinant human Histone deacetylase 1 | ChEMBL. | 14613312 |
IC50 (binding) | = 200 nM | Inhibition against partially purified human histone deacetylase 1 (HDAC-1) | ChEMBL. | 12061890 |
IC50 (binding) | = 200 nM | Inhibitory concentration against recombinant human Histone deacetylase 1 | ChEMBL. | 14613312 |
IC50 (binding) | = 200 nM | Inhibition against partially purified human histone deacetylase 1 (HDAC-1) | ChEMBL. | 12061890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.