Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Brugia malayi | SRC-1 | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.062 | 1 | 1 |
Entamoeba histolytica | SH2 domain containing protein | 0.0406 | 0.4624 | 0.4624 |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0406 | 0.4624 | 0.4624 |
Echinococcus multilocularis | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.062 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.062 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0406 | 0.4624 | 0.4624 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.062 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.062 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.062 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.062 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.062 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.062 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.062 | 1 | 1 |
Onchocerca volvulus | 0.062 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.062 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.062 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.062 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Displacement of Eu-MCH from human recombinant MCH-R1 expressed in CHO cell membrane after 90 mins by time-resolved fluorescence assay | ChEMBL. | 22137790 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.