Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | STE family protein kinase | 0.0135 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0135 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0135 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.1419 | 0.9065 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0135 | 0 | 0.5 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.1552 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0135 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0135 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0135 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.1093 | 0.6759 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0135 | 0 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.0135 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0135 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0135 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.1419 | 0.9065 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activation of EIF2alpha kinase in human CRL2351 cells assessed as CHOP mRNA expression at 5 uM after 5 hrs by PCR analysis | ChEMBL. | 22153346 | |
Activity (binding) | Activation of EIF2alpha kinase in mouse KLN205 cells assessed as phosphorylation of eIF2alpha at 20 uM after 5 hrs by Western blot analysis | ChEMBL. | 22153346 | |
Activity (binding) | Activation of EIF2alpha kinase in mouse KLN205 cells assessed as CHOP mRNA expression at 20 uM after 5 hrs by PCR analysis | ChEMBL. | 22153346 | |
Activity (binding) | Activation of EIF2alpha kinase in mouse KLN205 cells assessed as CHOP protein expression at 20 uM after 5 hrs by Western blot analysis | ChEMBL. | 22153346 | |
Activity (binding) | Activation of EIF2alpha kinase in human CRL2351 cells assessed as reduction in eIF2-GTP-initiator methionine tRNA ternary complex measuring increase in firefly/renilla luciferase ratio at 2.5 to 20 uM after 16 hrs by dual luciferase reporter gene assay relative to control | ChEMBL. | 22153346 | |
Activity (binding) | Activation of EIF2alpha kinase in human CRL2351 cells assessed as phosphorylation of eIF2alpha at 5 uM after 5 hrs by Western blot analysis | ChEMBL. | 22153346 | |
Activity (binding) | Activation of EIF2alpha kinase in human CRL2351 cells assessed as CHOP protein expression at 5 uM after 5 hrs by Western blot analysis | ChEMBL. | 22153346 | |
Ratio (binding) | < 2 | Activation of EIF2alpha kinase in human CRL2351 cells assessed as reduction in eIF2-GTP-initiator methionine tRNA ternary complex measuring increase in firefly/renilla luciferase ratio at 5 uM after 16 hrs by dual luciferase reporter gene assay relative to control | ChEMBL. | 22153346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.