Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.2325 | 0.9065 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.1784 | 0.6722 | 0.7416 |
Entamoeba histolytica | protein kinase, putative | 0.0231 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0237 | 0.0024 | 0.0026 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0237 | 0.0024 | 0.0035 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.1784 | 0.6722 | 0.6722 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.2541 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0231 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0237 | 0.0024 | 0.0026 |
Entamoeba histolytica | protein kinase, putative | 0.0231 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0237 | 0.0024 | 0.0024 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0237 | 0.0024 | 0.0024 |
Giardia lamblia | Kinase, STE STE20 | 0.1784 | 0.6722 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0231 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.1784 | 0.6722 | 0.7416 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0237 | 0.0024 | 0.0035 |
Trichomonas vaginalis | STE family protein kinase | 0.1784 | 0.6722 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.1784 | 0.6722 | 0.6715 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.1784 | 0.6722 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0231 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.1784 | 0.6722 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.1784 | 0.6722 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.2325 | 0.9065 | 1 |
Schistosoma mansoni | protein kinase | 0.1784 | 0.6722 | 1 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.1784 | 0.6722 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.1784 | 0.6722 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (ADMET) | = 4.11 % | Growth inhibition of human HepG2 cells at 20 uM after 48 hrs by MTT assay | ChEMBL. | 22197389 |
MIC (functional) | = 32 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 to 11 days by microdilution method | ChEMBL. | 22197389 |
MIC90 (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 to 11 days by microdilution method | ChEMBL. | 22197389 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.