Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.4268 | 0.2979 | 0.2079 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1323 | 0.0509 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3886 | 0.2659 | 0.3944 |
Loa Loa (eye worm) | hypothetical protein | 0.3191 | 0.2075 | 0.3079 |
Loa Loa (eye worm) | hypothetical protein | 0.3191 | 0.2075 | 0.3079 |
Leishmania major | carbonic anhydrase-like protein | 0.1323 | 0.0509 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0716 | 0 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.7077 | 0.5335 | 0.7501 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 1.2639 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1323 | 0.0509 | 0.1609 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1323 | 0.0509 | 0.0755 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.4485 | 0.3161 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1323 | 0.0509 | 0.0755 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1323 | 0.0509 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.3886 | 0.2659 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1323 | 0.0509 | 0.1609 |
Brugia malayi | Hemopexin family protein | 0.4268 | 0.2979 | 0.4419 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.3886 | 0.2659 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1323 | 0.0509 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.7077 | 0.5335 | 0.7914 |
Brugia malayi | Matrixin family protein | 0.3191 | 0.2075 | 0.3079 |
Schistosoma mansoni | hypothetical protein | 0.4268 | 0.2979 | 0.9423 |
Loa Loa (eye worm) | matrixin family protein | 0.8753 | 0.6741 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.3886 | 0.2659 | 0.3944 |
Brugia malayi | Matrixin family protein | 0.8753 | 0.6741 | 1 |
Brugia malayi | Matrixin family protein | 0.3191 | 0.2075 | 0.3079 |
Echinococcus granulosus | carbonic anhydrase II | 0.1323 | 0.0509 | 0.0509 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1323 | 0.0509 | 0.0755 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.3886 | 0.2659 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0716 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.8371 | 0.642 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4485 | 0.3161 | 0.469 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1323 | 0.0509 | 0.0509 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1323 | 0.0509 | 0.0755 |
Brugia malayi | Matrixin family protein | 0.3191 | 0.2075 | 0.3079 |
Brugia malayi | Matrixin family protein | 0.3191 | 0.2075 | 0.3079 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.1489 | 0.0648 | 0.2049 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.3191 | 0.2075 | 0.3079 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 64 % | Inhibition of Sprague-Dawley rat brain FAAH assessed as residual activity at 10 uM after 60 mins by reverse phase HPLC-based fluorescence method | ChEMBL. | 22196515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.