Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | pyruvate kinase | 0.0324 | 0.3551 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0324 | 0.3551 | 1 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0667 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0324 | 0.3551 | 0.3154 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0667 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0324 | 0.3551 | 0.2227 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.3551 | 0.2227 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0324 | 0.3551 | 0.5 |
Leishmania major | pyruvate kinase | 0.0324 | 0.3551 | 0.3551 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0667 | 1 | 1 |
Treponema pallidum | pyruvate phosphate dikinase | 0.0136 | 0 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0324 | 0.3551 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0324 | 0.3551 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0166 | 0.058 | 0.1633 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.063 | 0.9302 | 0.9259 |
Echinococcus multilocularis | pyruvate kinase | 0.0256 | 0.2265 | 0.1789 |
Leishmania major | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0233 | 0.1835 | 0.1835 |
Schistosoma mansoni | pyruvate kinase | 0.0324 | 0.3551 | 0.3154 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0226 | 0.1704 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0324 | 0.3551 | 0.3154 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0324 | 0.3551 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase kinase, putative | 0.0233 | 0.1835 | 0.4225 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0324 | 0.3551 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0324 | 0.3551 | 1 |
Wolbachia endosymbiont of Brugia malayi | pyruvate phosphate dikinase | 0.0136 | 0 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0324 | 0.3551 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.027 | 0.2534 | 0.6575 |
Loa Loa (eye worm) | pyruvate kinase | 0.0324 | 0.3551 | 0.2227 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0667 | 1 | 1 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0667 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0324 | 0.3551 | 0.3154 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0324 | 0.3551 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0667 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0324 | 0.3551 | 0.3154 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0324 | 0.3551 | 0.3551 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0324 | 0.3551 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0324 | 0.3551 | 0.2227 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0324 | 0.3551 | 0.3551 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0324 | 0.3551 | 0.3551 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.063 | 0.9302 | 0.9259 |
Chlamydia trachomatis | pyruvate kinase | 0.0324 | 0.3551 | 1 |
Leishmania major | pyruvate kinase | 0.0324 | 0.3551 | 0.3551 |
Trypanosoma brucei | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0233 | 0.1835 | 0.1835 |
Trypanosoma cruzi | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0233 | 0.1835 | 0.1835 |
Giardia lamblia | Pyruvate kinase | 0.0324 | 0.3551 | 1 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0667 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0324 | 0.3551 | 0.3154 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0324 | 0.3551 | 0.3551 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12 nM | Displacement of [3H]aldosterone from cytosolic human MR expressed in HEK293 cells after 16 hrs by scintillation counting | ChEMBL. | 22074142 |
IC50 (functional) | = 70 nM | Antagonist activity at human MR transfected in human COS1 cells after 1 day by luciferase reporter gene assay | ChEMBL. | 22074142 |
IC50 (binding) | = 200 nM | Displacement of [3H]dexomethasone from GR | ChEMBL. | 22074142 |
IC50 (binding) | = 930 nM | Displacement of [3H]progesterone from PR | ChEMBL. | 22074142 |
IC50 (binding) | = 4500 nM | Displacement of [3H]testosterone from AR | ChEMBL. | 22074142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.