Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Transient-receptor-potential like protein | 0.0032 | 0.021 | 0.021 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0043 | 0.0327 | 0.0251 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0112 | 0.109 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0043 | 0.0327 | 0.0119 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0112 | 0.109 | 0.109 |
Schistosoma mansoni | transient receptor potential channel | 0.0057 | 0.0484 | 0.0163 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0112 | 0.109 | 0.1021 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0926 | 1 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0112 | 0.109 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0112 | 0.109 | 0.0789 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0251 | 0.2611 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0179 | 0.0102 |
Schistosoma mansoni | transient receptor potential channel | 0.0086 | 0.0804 | 0.0493 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0083 | 0.0773 | 0.0574 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0112 | 0.109 | 0.109 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0926 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0112 | 0.109 | 0.109 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0112 | 0.109 | 0.1021 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0112 | 0.109 | 0.0899 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0452 | 0.0378 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0112 | 0.109 | 0.0899 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0112 | 0.109 | 0.0899 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0926 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0112 | 0.109 | 0.5 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0112 | 0.109 | 0.0789 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0043 | 0.0327 | 0.0119 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0083 | 0.0773 | 0.0574 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0112 | 0.109 | 0.109 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0926 | 1 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0112 | 0.109 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0043 | 0.0327 | 0.0119 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0057 | 0.0484 | 0.028 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0086 | 0.0804 | 0.0607 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0926 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0112 | 0.109 | 0.109 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0057 | 0.0484 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.2611 | 0.2553 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0926 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0057 | 0.0484 | 0.028 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0926 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0043 | 0.0327 | 0.0119 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0926 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0057 | 0.0484 | 0.0163 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0112 | 0.109 | 0.0789 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.021 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.2611 | 0.2553 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.109 | 0.1021 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0057 | 0.0484 | 0.028 |
Echinococcus multilocularis | muscleblind protein | 0.0251 | 0.2611 | 0.2452 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0643 | 0.6901 | 0.6835 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0112 | 0.109 | 0.0899 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0804 | 0.0732 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0112 | 0.109 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0086 | 0.0804 | 0.0493 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0043 | 0.0327 | 0.0327 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0086 | 0.0804 | 0.0607 |
Echinococcus granulosus | muscleblind protein | 0.0251 | 0.2611 | 0.2452 |
Brugia malayi | Muscleblind-like protein | 0.0251 | 0.2611 | 0.2611 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0926 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0926 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.