Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.061 | 0.3093 | 1 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.061 | 0.3093 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0859 | 0.5726 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.061 | 0.3093 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.1263 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1057 | 0.7822 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1263 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0859 | 0.5726 | 0.5 |
Brugia malayi | thymidylate synthase | 0.061 | 0.3093 | 0.3093 |
Loa Loa (eye worm) | thymidylate synthase | 0.061 | 0.3093 | 0.3093 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0859 | 0.5726 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.061 | 0.3093 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0859 | 0.5726 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.061 | 0.3093 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.061 | 0.3093 | 0.3955 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0859 | 0.5726 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0859 | 0.5726 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1057 | 0.7822 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.061 | 0.3093 | 0.3955 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | < 15 % | Agonist activity at human 5-HT6 serotonin receptor expressed in CHO-1 cells assessed as cAMP production relative to 5-hydroxytryptamine | ChEMBL. | 22290076 |
Kbapp (functional) | = 1.5 nM | Antagonist activity at human 5-HT6 serotonin receptor expressed in CHO-1 cells assessed as inhibition of 5-hydroxytryptamine-induced cAMP production | ChEMBL. | 22290076 |
Kbapp (functional) | = 1.6 nM | Antagonist activity at human 5-HT6 serotonin receptor expressed in CHO-1 cells assessed as inhibition of 5-hydroxytryptamine-induced cAMP production | ChEMBL. | 22290076 |
Ki (binding) | = 0.28 nM | Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay | ChEMBL. | 22290076 |
Ki (binding) | = 0.28 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 0.28 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 0.32 nM | Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay | ChEMBL. | 22290076 |
Ki (binding) | = 0.32 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 0.32 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 0.37 nM | Displacement of [3H]LSD from human 5-HT6 serotonin receptor by scintillation proximity assay | ChEMBL. | 22290076 |
Ki (binding) | = 0.37 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 0.37 nM | BindingDB_Patents: Binding Assay. The relative affinities of the various compounds for the 5-HT6 receptor were measured in a radioligand binding assay, using a sintillation proximity assay (SPA) format. | ChEMBL. | No reference |
permeability (ADMET) | = 0.55 ucm/s | Permeability from apical to basolateral side of human Caco2 cells | ChEMBL. | 22290076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.