Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.3149 | 0.3348 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.4289 | 0.5369 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.4289 | 0.5369 | 0.5369 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.4289 | 0.5369 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.4289 | 0.5369 | 0.5369 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.4289 | 0.5369 | 1 |
Brugia malayi | hypothetical protein | 0.2364 | 0.1957 | 0.1957 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.4289 | 0.5369 | 0.5369 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.6902 | 1 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.5372 | 0.7288 | 0.7288 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.6902 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.6902 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.6902 | 1 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.5372 | 0.7288 | 0.7288 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.4289 | 0.5369 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.6902 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2364 | 0.1957 | 0.1957 |
Brugia malayi | prolyl oligopeptidase family protein | 0.4289 | 0.5369 | 0.5369 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.4289 | 0.5369 | 1 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.5372 | 0.7288 | 0.7288 |
Loa Loa (eye worm) | hypothetical protein | 0.1925 | 0.1178 | 0.1178 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.292 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.