TDR Targets

Basic information

Technical information

TDR Targets ID: 161013
Name: 4-imidazol-1-yl-2-phenyl-3,4-dihydro-2H-chrom en-7-ol
MW: 292.332 | Formula: C18H16N2O2
H donors: 1 H acceptors: 2 LogP: 2.92 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc2c(c1)OC(CC2n1cncc1)c1ccccc1
InChi: 1S/C18H16N2O2/c21-14-6-7-15-16(20-9-8-19-12-20)11-17(22-18(15)10-14)13-4-2-1-3-5-13/h1-10,12,16-17,21H,11H2
InChiKey: ZVMPYRSCCMHXRC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-imidazol-1-yl-2-phenyl-chroman-7-ol
4-(1-imidazolyl)-2-phenyl-3,4-dihydro-2H-1-benzopyran-7-ol
4-imidazol-1-yl-2-phenylchroman-7-ol
4-(1-imidazolyl)-2-phenyl-7-chromanol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 19, subfamily A, polypeptide 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	cytochrome P450, putative	cytochrome P450, family 19, subfamily A, polypeptide 1	503 aa	425 aa	18.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0165	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	SH2 domain containing protein	0.0165	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0071	0.1121	0.1121
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0095	0.3382	0.2547
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0095	0.3382	0.2547
Brugia malayi	hypothetical protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0165	1	1
Plasmodium falciparum	protein kinase, putative	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0071	0.1121	0.1121
Echinococcus multilocularis	N chimaerin	0.0095	0.3382	0.2547
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0071	0.1121	0.1121
Toxoplasma gondii	STE kinase	0.0071	0.1121	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TK family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1121	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0165	1	1
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Onchocerca volvulus		0.0165	1	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0095	0.3382	0.3382
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0165	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0071	0.1121	0.1121
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0071	0.1121	0.1121
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0071	0.1121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0071	0.1121	0.1121
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0095	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0165	1	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0095	0.3382	0.2547
Onchocerca volvulus		0.0095	0.3382	0.2547
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0165	1	1
Onchocerca volvulus		0.0165	1	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Onchocerca volvulus		0.0095	0.3382	0.2547
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.1121	0.1121
Echinococcus multilocularis	SH2 motif	0.0095	0.3382	0.2547
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Echinococcus granulosus	tyrosine kinase	0.0165	1	1
Brugia malayi	protein-tyrosine kinase	0.0165	1	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Onchocerca volvulus		0.0165	1	1
Schistosoma mansoni	tensin	0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1121	0.1121
Brugia malayi	RhoGAP domain containing protein	0.0095	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0095	0.3382	0.2547
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0095	0.3382	0.2547
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0071	0.1121	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0165	1	1
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0071	0.1121	0.1121
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0165	1	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0071	0.1121	0.1121
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0071	0.1121	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0095	0.3382	0.2547
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0165	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0071	0.1121	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0071	0.1121	0.1121
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0165	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0165	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0095	0.3382	0.2547
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1121	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0095	0.3382	0.2547
Echinococcus granulosus	SH2 motif	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Schistosoma mansoni	tyrosine kinase	0.0165	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0095	0.3382	0.2547
Echinococcus granulosus	N chimaerin	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1121	0.1121
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0071	0.1121	0.1121
Brugia malayi	SRC-1	0.0165	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0165	1	1
Loa Loa (eye worm)	TK protein kinase	0.0165	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Brugia malayi	SH2 domain containing protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Schistosoma mansoni	shc transforming protein	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	SRC-1	0.0165	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0095	0.3382	0.2547
Brugia malayi	hypothetical protein	0.0095	0.3382	0.3382
Schistosoma mansoni	tyrosine kinase	0.0165	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0071	0.1121	0.1121
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Onchocerca volvulus		0.0095	0.3382	0.2547
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0095	0.3382	0.2547
Echinococcus granulosus	tensin	0.0095	0.3382	0.2547
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0165	1	1
Echinococcus multilocularis	SHC transforming protein 3	0.0095	0.3382	0.2547
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0095	0.3382	0.2547
Echinococcus granulosus	tyrosine protein kinase Blk	0.0165	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0165	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0095	0.3382	0.2547
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	SH2 domain containing protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0071	0.1121	0.1121
Echinococcus granulosus	signal transduction protein lnk realted	0.0095	0.3382	0.2547
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0165	1	1
Onchocerca volvulus		0.0095	0.3382	0.2547
Brugia malayi	hypothetical protein	0.0165	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0165	1	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0095	0.3382	0.3382
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0071	0.1121	0.1121
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus granulosus	SH2 motif	0.0095	0.3382	0.2547
Schistosoma mansoni	nck2/grb4	0.0095	0.3382	0.2547
Giardia lamblia	Kinase, NEK	0.0071	0.1121	0.5
Trypanosoma cruzi	protein kinase, putative	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0165	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0095	0.3382	0.2547
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0165	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus multilocularis	SH2 motif	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Brugia malayi	SH2 domain containing protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Brugia malayi	Furin-like cysteine rich region family protein	0.0071	0.1121	0.1121
Onchocerca volvulus		0.0095	0.3382	0.2547
Schistosoma mansoni	suppressor of cytokine signaling	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0165	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0071	0.1121	0.5
Schistosoma mansoni	tyrosine kinase	0.0165	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1121	0.1121
Echinococcus multilocularis		0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0071	0.1121	0.1121
Schistosoma mansoni	tensin	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.3382	0.3382
Schistosoma mansoni	hypothetical protein	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Plasmodium falciparum	protein kinase, putative	0.0071	0.1121	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0165	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0095	0.3382	0.2547
Brugia malayi	SH2 domain containing protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0165	1	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0095	0.3382	0.2547
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0095	0.3382	0.2547
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0165	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Brugia malayi	Sex muscle abnormal protein 5	0.0095	0.3382	0.3382
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Toxoplasma gondii	protein kinase domain-containing protein	0.0071	0.1121	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0071	0.1121	0.1121
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0165	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0071	0.1121	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0095	0.3382	0.2547
Schistosoma mansoni	tensin-related	0.0095	0.3382	0.2547
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0071	0.1121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Schistosoma mansoni	tyrosine kinase	0.0165	1	1
Echinococcus granulosus	hypothetical protein	0.0095	0.3382	0.2547
Schistosoma mansoni	tensin-related	0.0095	0.3382	0.2547
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0095	0.3382	0.2547
Brugia malayi	Tensin	0.0095	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0095	0.3382	0.2547
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0165	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0095	0.3382	0.2547
Trypanosoma cruzi	protein kinase, putative	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	integrin-linked kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Schistosoma mansoni	hypothetical protein	0.0095	0.3382	0.2547
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Echinococcus multilocularis	tyrosine protein kinase shark	0.0165	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.3382	0.3382
Schistosoma mansoni	growth factor receptor-bound protein	0.0095	0.3382	0.2547
Echinococcus multilocularis	tensin	0.0095	0.3382	0.2547
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0165	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0095	0.3382	0.3382
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Schistosoma mansoni	adapter molecule crk	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	hypothetical protein	0.0071	0.1121	0.1121
Brugia malayi	Guanylyl cyclase protein 23	0.0071	0.1121	0.1121
Giardia lamblia	Kinase, NEK	0.0071	0.1121	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1121	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0165	1	1
Toxoplasma gondii	protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0071	0.1121	0.5
Schistosoma mansoni	vav2	0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Echinococcus multilocularis	SH2 motif	0.0095	0.3382	0.2547
Schistosoma mansoni	tyrosine kinase	0.0165	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0165	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0071	0.1121	0.5
Onchocerca volvulus		0.0165	1	1
Leishmania major	protein kinase, putative	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0165	1	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	protein kinase atn1, putative	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0165	1	1
Schistosoma mansoni	tensin	0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Giardia lamblia	Kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	TK/INSR protein kinase	0.0071	0.1121	0.1121
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0165	1	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Echinococcus multilocularis	c src tyrosine kinase	0.0165	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	STE family protein kinase	0.0071	0.1121	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Onchocerca volvulus		0.0095	0.3382	0.2547
Trypanosoma brucei	protein kinase, putative	0.0071	0.1121	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0165	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0165	1	1
Plasmodium falciparum	protein kinase, putative	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Leishmania major	hypothetical protein, conserved	0.0071	0.1121	0.5
Echinococcus granulosus	NCK adaptor protein	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0071	0.1121	0.1121
Echinococcus multilocularis	SH2 domain containing protein 7	0.0095	0.3382	0.2547
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0165	1	1
Echinococcus granulosus	expressed conserved protein	0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK/EPH protein kinase	0.0071	0.1121	0.1121
Echinococcus granulosus	tyrosine protein kinase shark	0.0165	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0095	0.3382	0.2547
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	TK/FER protein kinase	0.0165	1	1
Echinococcus multilocularis	tyrosine kinase	0.0165	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Schistosoma mansoni	GTPase activating protein	0.0095	0.3382	0.2547
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Schistosoma mansoni	SH2A	0.0095	0.3382	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Brugia malayi	SH2 domain containing protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0095	0.3382	0.3382
Plasmodium vivax	protein kinase, putative	0.0071	0.1121	0.5
Schistosoma mansoni	signal transduction protein lnk-related	0.0095	0.3382	0.2547
Brugia malayi	Tyrosine-protein kinase PR2	0.0071	0.1121	0.1121
Onchocerca volvulus		0.0165	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0095	0.3382	0.2547
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Onchocerca volvulus		0.0165	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0165	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0071	0.1121	0.5
Leishmania major	protein kinase, putative	0.0071	0.1121	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0095	0.3382	0.2547
Loa Loa (eye worm)	SH2 domain-containing protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1121	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0165	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1121	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1121	0.1121
Echinococcus multilocularis	tensin	0.0095	0.3382	0.2547
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0095	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1121	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0095	0.3382	0.2547
Giardia lamblia	Protein 21.1	0.0071	0.1121	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0071	0.1121	0.1121
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Echinococcus granulosus	tyrosine kinase	0.0165	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Entamoeba histolytica	protein kinase, putative	0.0095	0.3382	0.2547
Brugia malayi	SH2 domain containing protein	0.0165	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0165	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	SH2 domain containing protein	0.0095	0.3382	0.3382
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0095	0.3382	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1121	0.1121
Schistosoma mansoni	tyrosine kinase	0.0165	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0071	0.1121	0.5
Loa Loa (eye worm)	STAT protein	0.0095	0.3382	0.3382
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0165	1	1
Brugia malayi	SH2 domain containing protein	0.0095	0.3382	0.3382
Brugia malayi	Protein kinase domain containing protein	0.0165	1	1
Brugia malayi	Protein kinase domain containing protein	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0165	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0071	0.1121	0.1121
Loa Loa (eye worm)	SH2 domain-containing protein	0.0095	0.3382	0.3382
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0071	0.1121	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Brugia malayi	Raf kinase	0.0071	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3382	0.3382
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0071	0.1121	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0071	0.1121	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.04 uM	In vitro inhibition of [1,2,6,7-3H]androstenedione binding to Aromatase of human placental microsomes	ChEMBL.	15380230
IC50 (binding)	= 0.04 uM	In vitro inhibition of [1,2,6,7-3H]androstenedione binding to Aromatase of human placental microsomes	ChEMBL.	15380230
IC50 (binding)	= 0.041 uM	Inhibition of aromatase activity in human placental microsomes	ChEMBL.	12270163
IC50 (binding)	= 0.041 uM	Inhibition of aromatase activity in human placental microsomes	ChEMBL.	12270163
Relative potency (binding)	= 93	Relative potency for aromatase inhibition in human placental microsomes compared to flavanone	ChEMBL.	12270163
Relative Potency (binding)	= 126.8	Relative potency for inhibition of aromatase binding compared to aminoglutethimide	ChEMBL.	15380230
Relative potency (binding)	= 127	Relative potency for aromatase inhibition in human placental microsomes compared to aminoglutethimide	ChEMBL.	12270163
Relative potency (binding)	= 93	Relative potency for aromatase inhibition in human placental microsomes compared to flavanone	ChEMBL.	12270163
Relative Potency (binding)	= 126.8	Relative potency for inhibition of aromatase binding compared to aminoglutethimide	ChEMBL.	15380230
Relative potency (binding)	= 127	Relative potency for aromatase inhibition in human placental microsomes compared to aminoglutethimide	ChEMBL.	12270163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL95919
PubChem: 11779089

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 161013