Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Ankyrin | 0.0047 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0332 | 0.5867 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.7494 | 1 |
Echinococcus granulosus | jun protein | 0.0423 | 0.7732 | 0.7732 |
Brugia malayi | bZIP transcription factor family protein | 0.0423 | 0.7732 | 1 |
Schistosoma mansoni | jun-related protein | 0.0343 | 0.6105 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0423 | 0.7732 | 0.7732 |
Echinococcus multilocularis | jun protein | 0.0423 | 0.7732 | 0.7732 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0423 | 0.7732 | 0.7732 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0047 | 0.0005 | 0.0008 |
Brugia malayi | hypothetical protein | 0.0332 | 0.5867 | 0.7588 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0533 | 1 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0047 | 0.0005 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.6105 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 19 % | The compound was evaluated for irreversible inhibition of HIV-1 protease at 20 microM | ChEMBL. | No reference |
Inhibition (binding) | = 19 % | The compound was evaluated for irreversible inhibition of HIV-1 protease at 20 microM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.