Detailed information for compound 1610682

Basic information

Technical information
  • TDR Targets ID: 1610682
  • Name: 2-hydroxy-2-(3-methylphenyl)-2-phenylacetic a cid
  • MW: 242.27 | Formula: C15H14O3
  • H donors: 2 H acceptors: 3 LogP: 2.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)C(c1ccccc1)(C(=O)O)O
  • InChi: 1S/C15H14O3/c1-11-6-5-9-13(10-11)15(18,14(16)17)12-7-3-2-4-8-12/h2-10,18H,1H3,(H,16,17)
  • InChiKey: KMTWMSGNLPWRGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxy-2-(3-methylphenyl)-2-phenyl-acetic acid
  • 2-hydroxy-2-(3-methylphenyl)-2-phenyl-ethanoic acid
  • NSC121786

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0142 0.6825 0.6825
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0142 0.6825 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0142 0.6825 0.6825
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0128 0.5721 0.8383
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0142 0.6825 0.5
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0142 0.6825 0.5
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0142 0.6825 0.5
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0142 0.6825 0.5
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0142 0.6825 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.039 0.039
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0142 0.6825 0.5
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0142 0.6825 0.5
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0142 0.6825 1
Echinococcus granulosus lysosomal protective protein 0.0142 0.6825 1
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0128 0.5721 0.8383
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.039 0.039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.039 0.039
Echinococcus multilocularis lysosomal protective protein 0.0142 0.6825 1
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0142 0.6825 0.5
Onchocerca volvulus 0.0182 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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