Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0362 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0555 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0197 | 0.0197 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.1017 | 0.1017 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0197 | 0.0197 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0362 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0197 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0555 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0197 | 0.0197 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0555 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0555 | 0.0555 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0197 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0555 | 1 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0362 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0197 | 0.0197 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0492 | 0.0492 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0362 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0362 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0362 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0362 | 1 | 1 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0327 | 0.8948 | 0.8948 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0555 | 0.0555 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0197 | 0.5 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0327 | 0.8948 | 0.8948 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0362 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0362 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0555 | 0.0555 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0362 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.1017 | 0.1017 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0492 | 0.0492 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0362 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0197 | 0.0197 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0036 | 0.0409 | 0.0409 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0362 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0492 | 0.0492 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.1017 | 0.1017 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1017 | 0.1017 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0197 | 0.0197 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0555 | 0.0555 |
Echinococcus multilocularis | lysosomal protective protein | 0.0362 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.