Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.5 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0117 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.5 | 0.5 | |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0117 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Echinococcus granulosus | Mastin | 0.0117 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.5 | 0.5 | |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0117 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0117 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0117 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0117 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0117 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.5 | 0.5 | |
Echinococcus multilocularis | Mastin | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0117 | 0.5 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0117 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.