Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.1634 | 0.5727 |
Onchocerca volvulus | 0.0256 | 0.2853 | 0.5 | |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0601 | 1 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0197 | 0.1634 | 0.5727 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0256 | 0.2853 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.7736 | 0.7493 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0309 | 0.3945 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0256 | 0.2853 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0326 | 0.4311 | 0.204 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0601 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0256 | 0.2853 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0256 | 0.2853 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.3945 | 0.1675 |
Chlamydia trachomatis | SWIB complex protein | 0.0256 | 0.2853 | 0.5 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0197 | 0.1634 | 0.5727 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0197 | 0.1634 | 0.5727 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0309 | 0.3945 | 0.1527 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0256 | 0.2853 | 1 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0167 | 0.1003 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0256 | 0.2853 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0256 | 0.2853 | 0.5 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0167 | 0.1003 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0326 | 0.4311 | 0.204 |
Loa Loa (eye worm) | hypothetical protein | 0.057 | 0.937 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0256 | 0.2853 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.