Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0942 | 0.6607 | 0.6607 |
Toxoplasma gondii | MAPEG family protein | 0.1412 | 1 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0028 | 0 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Brugia malayi | SRC-1 | 0.0028 | 0 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0942 | 0.6607 | 0.6607 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.1412 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.1412 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0028 | 0 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0942 | 0.6607 | 0.6607 |
Loa Loa (eye worm) | TK protein kinase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0921 | 0.6451 | 0.6451 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | protein-tyrosine kinase | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.1412 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.203 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.