Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | acetyl-CoA transporter, putative | 0.5707 | 0.5702 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4082 | 0.1777 | 0.1655 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.5707 | 0.5702 | 0.5702 |
Echinococcus multilocularis | solute carrier family 33 | 0.5707 | 0.5702 | 0.5639 |
Loa Loa (eye worm) | hypothetical protein | 0.5707 | 0.5702 | 0.5639 |
Brugia malayi | Protein C21B10.09 in chromosome II | 0.5707 | 0.5702 | 0.5639 |
Schistosoma mansoni | tyrosine kinase | 0.7487 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.7487 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.3406 | 0.0146 | 0.0146 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.7487 | 1 | 1 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.5707 | 0.5702 | 0.5702 |
Schistosoma mansoni | tyrosine kinase | 0.3406 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.7487 | 1 | 1 |
Echinococcus granulosus | solute carrier family 33 | 0.5707 | 0.5702 | 0.5639 |
Echinococcus multilocularis | insulin receptor | 0.7487 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.3406 | 0.0146 | 0.0146 |
Brugia malayi | Protein C21B10.09 in chromosome II | 0.5707 | 0.5702 | 0.5639 |
Toxoplasma gondii | Acetyl-coenzyme A transporter, putative | 0.5707 | 0.5702 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.7487 | 1 | 1 |
Echinococcus granulosus | insulin receptor | 0.7487 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.4142 | 0.1923 | 0.1803 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.142 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.918 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.51 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.433 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.212 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.163 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.141 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.06 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.