Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Estrogen receptor alpha | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7300 nM | Binding to Estrogen receptor- alpha (ER alpha) receptor | ChEMBL. | 12270167 |
IC50 (binding) | = 7300 nM | Binding to Estrogen receptor- alpha (ER alpha) receptor | ChEMBL. | 12270167 |
IC50 (binding) | ~ 100000 nM | Binding to Estrogen receptor- beta (ER beta) receptor | ChEMBL. | 12270167 |
IC50 (binding) | ~ 100000 nM | Binding to Estrogen receptor- beta (ER beta) receptor | ChEMBL. | 12270167 |
Selectivity (binding) | = 14 | Selectivity as ratio of IC50 against ER beta receptor to IC50 against ER alpha receptor | ChEMBL. | 12270167 |
Selectivity (binding) | = 14 | Selectivity as ratio of IC50 against ER beta receptor to IC50 against ER alpha receptor | ChEMBL. | 12270167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.