Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0253 | 0.4742 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.4584 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0401 | 0.9326 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0401 | 0.9326 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0401 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0253 | 0.4742 | 0.0000097958 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0401 | 0.9326 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0401 | 0.9326 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0401 | 0.9326 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0401 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0401 | 0.9326 | 0.9122 |
Brugia malayi | valosin containing protein | 0.0248 | 0.4584 | 1 |
Giardia lamblia | AAA family ATPase | 0.0253 | 0.4742 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.0248 | 0.4584 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0248 | 0.4584 | 1 |
Mycobacterium ulcerans | ATPase | 0.0253 | 0.4742 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.777 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.758 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.71 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.677 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.676 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.652 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.626 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.58 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.496 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.