TDR Targets

Basic information

Technical information

TDR Targets ID: 161548
Name: 4-cyclohexyl-7-nitro-6-pyrrol-1-yl-1H-quinoxa line-2,3-dione
MW: 354.36 | Formula: C18H18N4O4
H donors: 1 H acceptors: 4 LogP: 2.67 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1c(=O)[nH]c2c(n1C1CCCCC1)cc(c(c2)[N+](=O)[O-])n1cccc1
InChi: 1S/C18H18N4O4/c23-17-18(24)21(12-6-2-1-3-7-12)14-11-15(20-8-4-5-9-20)16(22(25)26)10-13(14)19-17/h4-5,8-12H,1-3,6-7H2,(H,19,23)
InChiKey: DQHACVVBVVEAAG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-cyclohexyl-7-nitro-6-(1-pyrrolyl)-1H-quinoxaline-2,3-dione
4-cyclohexyl-7-nitro-6-pyrrol-1-yl-1H-quinoxaline-2,3-quinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Starlite/ChEMBL	No references
Mus musculus	glutamate receptor, ionotropic, AMPA4 (alpha 4)		No references
Mus musculus	glutamate receptor, ionotropic, AMPA3 (alpha 3)		No references
Mus musculus	glutamate receptor, ionotropic, AMPA2 (alpha 2)		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 1 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 2 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA1 (alpha 1)	907 aa	780 aa	33.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glutamate receptor 4	0.0204	0.0421	0.0421
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0249	0.0648	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.07	0.2935	0.5699
Echinococcus multilocularis	serotonin receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Onchocerca volvulus	Putative GMP reductase	0.0309	0.0954	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0135	0.0068	0.0068
Toxoplasma gondii	hypothetical protein	0.1133	0.5133	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	histamine h1 receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0372	0.1272	0.1272
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.2091	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0219	0.0495	0.0495
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	carbonic anhydrase-related	0.1133	0.5133	0.5133
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	g protein coupled receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	glutamate receptor 2	0.0348	0.1152	0.1152
Echinococcus multilocularis	neuropeptide Y receptor	0.0135	0.0068	0.0068
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.2091	1	1
Schistosoma mansoni	amine GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0135	0.0068	0.0068
Schistosoma mansoni	opsin-like receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	G-protein coupled receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	glutamate receptor 1	0.0325	0.1036	0.1036
Echinococcus multilocularis	neuropeptide s receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	carbonic anhydrase	0.1133	0.5133	0.5133
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0348	0.1152	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.2091	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	7TM GPCR rhodopsin	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	neuropeptides capa receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	serotonin receptor	0.0135	0.0068	0.0068
Leishmania major	carbonic anhydrase-like protein	0.2091	1	1
Echinococcus multilocularis	somatostatin receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	hypothetical protein	0.1133	0.5133	0.5133
Brugia malayi	Glutamate receptor 1 precursor	0.0325	0.1036	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0421	0.0421
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.07	0.2935	1
Schistosoma mansoni	opsin-like receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	glutamate receptor 2	0.0325	0.1036	0.1036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0135	0.0068	0.0068
Plasmodium falciparum	carbonic anhydrase	0.1133	0.5133	1
Echinococcus multilocularis	carbonic anhydrase	0.1133	0.5133	0.5133
Trypanosoma brucei	carbonic anhydrase-like protein	0.2091	1	1
Echinococcus granulosus	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	neuropeptide receptor	0.1904	0.9051	0.9051
Schistosoma mansoni	glutamate receptor NMDA	0.0144	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0421	0.0421
Schistosoma mansoni	amine GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	carbonic anhydrase-related	0.1133	0.5133	0.5133
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0126	0.0023	0.0023
Echinococcus multilocularis	g protein coupled receptor	0.0135	0.0068	0.0068
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.07	0.2935	0.9907
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Echinococcus granulosus	G protein coupled receptor 139	0.0135	0.0068	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0219	0.0495	0.0429
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	neuropeptides capa receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	glutamate receptor 2	0.0303	0.0925	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0135	0.0068	0.0068
Echinococcus multilocularis	neuropeptide receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.1133	0.5133	0.5133
Loa Loa (eye worm)	TYRA-2 protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.1133	0.5133	0.5133
Echinococcus granulosus	serotonin receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	glutamate receptor 4	0.0204	0.0421	0.0421
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0348	0.1152	0.1152
Echinococcus granulosus	g-protein coupled receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0219	0.0495	0.0495
Loa Loa (eye worm)	carbonic anhydrase 3	0.2091	1	1
Echinococcus granulosus	glutamate receptor 1	0.0204	0.0421	0.0421
Echinococcus granulosus	carbonic anhydrase II	0.2091	1	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	allatostatin A receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	g-protein coupled receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus granulosus	neuropeptide Y receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	neuropeptide F-like receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0135	0.0068	0.0068
Echinococcus multilocularis	neuropeptide receptor A26	0.0135	0.0068	0.0068
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	sex peptide receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Echinococcus granulosus	somatostatin receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	orexin receptor type 2	0.0135	0.0068	0.0068
Echinococcus granulosus	tm gpcr rhodopsin	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0703	0.2954	0.5
Schistosoma mansoni	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0135	0.0068	0.0068
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0372	0.1272	0.1272
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1133	0.5133	0.51
Echinococcus granulosus	neuropeptide receptor	0.1904	0.9051	0.9051
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0309	0.0954	0.0892
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0219	0.0495	0.0495
Schistosoma mansoni	amine GPCR	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	amine GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	carbonic anhydrase	0.1133	0.5133	0.5133
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0309	0.0954	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0703	0.2954	0.2954
Echinococcus granulosus	neuropeptide FF receptor 2	0.0372	0.1272	0.1272
Echinococcus granulosus	neuropeptide s receptor	0.0135	0.0068	0.0068
Toxoplasma gondii	IMP dehydrogenas	0.0703	0.2954	0.5735
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0144	0.0117	0.0117
Echinococcus granulosus	tm gpcr rhodopsin	0.0135	0.0068	0.0068
Loa Loa (eye worm)	GMP reductase	0.0309	0.0954	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0135	0.0068	0.0068
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0219	0.0495	0.0495
Loa Loa (eye worm)	neuropeptide F receptor	0.0135	0.0068	0.0068
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0703	0.2954	1
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0249	0.0648	0.0648
Schistosoma mansoni	neuropeptide f receptor 76f	0.0135	0.0068	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0703	0.2954	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	dro:myosuppressin receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	biogenic amine 5HT receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0254	0.0675	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	g protein coupled receptor	0.0135	0.0068	0.0068
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0703	0.2954	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0135	0.0068	0.0068
Echinococcus granulosus	neuropeptide receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	biogenic amine receptor	0.0135	0.0068	0.0068
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1133	0.5133	0.51
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.2091	1	1
Echinococcus granulosus	carbonic anhydrase	0.1133	0.5133	0.5133
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.2091	1	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0144	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus granulosus	allatostatin A receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	carbonic anhydrase-related	0.1133	0.5133	0.5133
Schistosoma mansoni	myosin xvIII	0.0135	0.0068	0.0068
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0703	0.2954	0.2954
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.039	0.1367	0.1992
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0144	0.0117	0.0117
Echinococcus granulosus	tm gpcr rhodopsin	0.0135	0.0068	0.0068
Brugia malayi	GMP reductase	0.0309	0.0954	0.0892
Schistosoma mansoni	amine GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	orexin receptor type 2	0.0135	0.0068	0.0068
Echinococcus granulosus	fmrfamide receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	neuropeptides capa receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	neuropeptide Y receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0135	0.0068	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Echinococcus granulosus	biogenic amine 5HT receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0135	0.0068	0.0068
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	neuropeptide receptor	0.1904	0.9051	0.9051
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0421	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0135	0.0068	0.0068
Schistosoma mansoni	hypothetical protein	0.0135	0.0068	0.0068
Schistosoma mansoni	neuropeptide F-like receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0144	0.0117	0.0117
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Loa Loa (eye worm)	G-protein coupled receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0703	0.2954	0.2954
Brugia malayi	Glutamate receptor 2 precursor	0.0325	0.1036	0.0974
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0135	0.0068	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	dro:myosuppressin receptor	0.0135	0.0068	0.0068
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.1133	0.5133	0.51
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	fmrfamide receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	neuropeptide F receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0144	0.0117	0.0117
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	neuropeptides capa receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	carbonic anhydrase	0.1133	0.5133	0.5133
Echinococcus granulosus	sex peptide receptor	0.0135	0.0068	0.0068
Echinococcus multilocularis	G protein coupled receptor 139	0.1904	0.9051	0.9051
Schistosoma mansoni	opsin-like receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0703	0.2954	0.2954
Echinococcus granulosus	neuropeptide receptor A26	0.0135	0.0068	0.0068
Echinococcus granulosus	carbonic anhydrase	0.1133	0.5133	0.5133
Echinococcus multilocularis	fmrfamide receptor	0.0135	0.0068	0.0068
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0703	0.2954	0.2906
Schistosoma mansoni	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus granulosus	g protein coupled receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.1133	0.5133	0.5133
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.2091	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0135	0.0068	0.0068
Echinococcus multilocularis	carbonic anhydrase II	0.2091	1	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0135	0.0068	0.0068
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0135	0.0068	0.0068
Echinococcus granulosus	g protein coupled receptor	0.0135	0.0068	0.0068
Schistosoma mansoni	adenoreceptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0372	0.1272	0.1212
Echinococcus multilocularis	carbonic anhydrase	0.1133	0.5133	0.5133
Echinococcus granulosus	7tm_1 domain containing protein	0.0135	0.0068	0.0068
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0135	0.0068	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Echinococcus granulosus	glutamate receptor 2	0.0348	0.1152	0.1152
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0144	0.0117	0.0117
Echinococcus granulosus	g protein coupled receptor	0.0135	0.0068	0.0068
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1133	0.5133	0.51
Echinococcus granulosus	glutamate receptor 2	0.0303	0.0925	0.0925
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.1133	0.5133	0.51
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0135	0.0068	0.0068
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0126	0.0023	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0135	0.0068	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.1133	0.5133	0.5133
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068
Echinococcus multilocularis	neuropeptide Y receptor	0.0135	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0068	0.0068

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 22 mg kg-1	In vivo AMPA antagonistic activity was determined by measuring ability to antagonize AMPA induced lethal convulsions in mice at 60 min upon intraperitoneal administration	ChEMBL.	No reference
ED50 (functional)	= 22 mg kg-1	In vivo AMPA antagonistic activity was determined by measuring ability to antagonize AMPA induced lethal convulsions in mice at 60 min upon intraperitoneal administration	ChEMBL.	No reference
ED50 (functional)	> 50 mg kg-1	In vivo AMPA antagonistic activity was determined by measuring ability to antagonize AMPA induced lethal convulsions in mice at 15 min upon intraperitoneal administration	ChEMBL.	No reference
ED50 (functional)	> 50 mg kg-1	In vivo AMPA antagonistic activity was determined by measuring ability to antagonize AMPA induced lethal convulsions in mice at 15 min upon intraperitoneal administration	ChEMBL.	No reference
Ki (binding)	uM	Compound was tested for binding affinity against Ionotropic glutamate receptor kainate using [3H]-kainate as a radioligand.; Not tested	ChEMBL.	No reference
Ki (binding)	uM	Compound was tested for binding affinity against glycine site of NMDA receptor using [3H]-glycine as a radioligand; Not tested	ChEMBL.	No reference
Ki (binding)	0 uM	Compound was tested for binding affinity against glycine site of NMDA receptor using [3H]-glycine as a radioligand; Not tested	ChEMBL.	No reference
Ki (binding)	0 uM	Compound was tested for binding affinity against Ionotropic glutamate receptor kainate using [3H]-kainate as a radioligand.; Not tested	ChEMBL.	No reference
Ki (binding)	= 0.4 uM	Compound was tested for binding affinity against Ionotropic glutamate receptor AMPA using [3H]-AMPA as a radioligand.	ChEMBL.	No reference
Ki (binding)	= 0.4 uM	Compound was tested for binding affinity against Ionotropic glutamate receptor AMPA using [3H]-AMPA as a radioligand.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL414411
PubChem: 22097098

Bibliographic References

No literature references available for this target.

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Detailed information for compound 161548