Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2735 | 0.2735 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0206 | 0.4861 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0124 | 0.2735 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2735 | 0.2735 |
Loa Loa (eye worm) | glutamate receptor | 0.0072 | 0.1389 | 0.1389 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0089 | 0.182 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.182 | 0.182 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0065 | 0.1213 | 0.1213 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.006 | 0.1086 | 0.1466 |
Loa Loa (eye worm) | glutamate receptor | 0.0028 | 0.0256 | 0.0256 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0035 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2735 | 0.2735 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0124 | 0.2735 | 0.2735 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0089 | 0.182 | 0.0824 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0072 | 0.1389 | 0.1389 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0207 | 0.4894 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0082 | 0.1645 | 0.2719 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0206 | 0.4861 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.