Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0174 | 0.0365 | 0.0365 |
Onchocerca volvulus | Putative eukaryotic translation initiation factor 4e | 0.0174 | 0.0365 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0174 | 0.0365 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0684 | 0.4185 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0684 | 0.4185 | 0.5 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 0.4185 | 0.5 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0174 | 0.0365 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 0.4185 | 1 |
Giardia lamblia | Hypothetical protein | 0.0174 | 0.0365 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0174 | 0.0365 | 0.5 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0174 | 0.0365 | 0.5 |
Giardia lamblia | Translation elongation factor | 0.0174 | 0.0365 | 0.5 |
Giardia lamblia | hypothetical protein | 0.0174 | 0.0365 | 0.5 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0174 | 0.0365 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0174 | 0.0365 | 0.0365 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.523 | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
IC50 (binding) | = 3 uM | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
IC50 (binding) | > 200 uM | Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's method | ChEMBL. | 22297115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.