Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0039 | 0.1315 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0039 | 0.1315 | 0.1355 |
Echinococcus multilocularis | serine:threonine protein kinase Nek1 | 0.0152 | 0.9707 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0039 | 0.1315 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Cation transporter family protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0039 | 0.1315 | 0.1315 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0039 | 0.1315 | 0.1355 |
Onchocerca volvulus | 0.0039 | 0.1315 | 1 | |
Onchocerca volvulus | 0.0039 | 0.1315 | 1 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0039 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0039 | 0.1315 | 0.1355 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0039 | 0.1315 | 0.1355 |
Onchocerca volvulus | 0.0039 | 0.1315 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0039 | 0.1315 | 0.1315 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0039 | 0.1315 | 0.1355 |
Schistosoma mansoni | nAChR subunit | 0.0039 | 0.1315 | 0.1315 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0039 | 0.1315 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0039 | 0.1315 | 0.1355 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0039 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0039 | 0.1315 | 0.1315 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0039 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0039 | 0.1315 | 0.1355 |
Onchocerca volvulus | 0.0039 | 0.1315 | 1 | |
Echinococcus granulosus | glycine receptor subunit beta | 0.0039 | 0.1315 | 0.1355 |
Onchocerca volvulus | 0.0039 | 0.1315 | 1 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0039 | 0.1315 | 0.1355 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0039 | 0.1315 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0039 | 0.1315 | 0.1315 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0039 | 0.1315 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | LGC-31 protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Cation transporter family protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Cation transporter family protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0039 | 0.1315 | 0.1315 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0039 | 0.1315 | 0.1355 |
Echinococcus granulosus | serine:threonine protein kinase Nek1 | 0.0152 | 0.9707 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0039 | 0.1315 | 0.1355 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0039 | 0.1315 | 0.1355 |
Echinococcus granulosus | nAChR subunit | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0039 | 0.1315 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0039 | 0.1315 | 1 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0039 | 0.1315 | 0.1355 |
Schistosoma mansoni | nAChR subunit | 0.0039 | 0.1315 | 0.1315 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0039 | 0.1315 | 0.1355 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0039 | 0.1315 | 0.1355 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0039 | 0.1315 | 0.1355 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0039 | 0.1315 | 0.1315 |
Schistosoma mansoni | nAChR subunit | 0.0039 | 0.1315 | 0.1315 |
Schistosoma mansoni | nAChR subunit | 0.0039 | 0.1315 | 0.1315 |
Onchocerca volvulus | 0.0039 | 0.1315 | 1 | |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0039 | 0.1315 | 0.1355 |
Onchocerca volvulus | Putative nachr subunit | 0.0039 | 0.1315 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0039 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0039 | 0.1315 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1315 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.486 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.25 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.946 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.925 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.915 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.901 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.852 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.