Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0598 | 0.0848 | 1 | |
Echinococcus multilocularis | MAM | 0.0532 | 0.0694 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0068 | 0.0068 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.05 | 0.0619 | 0.5692 |
Loa Loa (eye worm) | hypothetical protein | 0.3043 | 0.6553 | 0.6556 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0597 | 0.0846 | 0.0783 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.05 | 0.0619 | 0.0828 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0735 | 0.1168 | 0.1651 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0291 | 0.0131 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 0.0694 | 0.0694 |
Schistosoma mansoni | hypothetical protein | 0.0532 | 0.0694 | 0.6458 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0273 | 0.0089 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.4518 | 0.9997 | 1 |
Echinococcus granulosus | tyrosine protein kinase | 0.3118 | 0.6729 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.05 | 0.0619 | 0.0828 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0291 | 0.0131 | 0.0063 |
Brugia malayi | hypothetical protein | 0.0532 | 0.0694 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 0.0694 | 0.0694 |
Brugia malayi | Protein kinase domain containing protein | 0.3118 | 0.6729 | 0.6707 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0679 | 0.1037 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0532 | 0.0694 | 0.6458 |
Echinococcus granulosus | MAM | 0.0532 | 0.0694 | 0.0939 |
Loa Loa (eye worm) | glutamate receptor | 0.0597 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0735 | 0.1168 | 0.1168 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0541 | 0.0715 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0273 | 0.0089 | 0.0089 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0735 | 0.1168 | 0.1651 |
Loa Loa (eye worm) | hypothetical protein | 0.3911 | 0.8579 | 0.8582 |
Echinococcus multilocularis | tyrosine protein kinase | 0.3118 | 0.6729 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.3118 | 0.6729 | 0.6732 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.771 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.771 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.683 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.613 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.588 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.518 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.447 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.389 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.363 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.221 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.