Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.079 | 1 | 1 |
Onchocerca volvulus | 0.0451 | 0.5502 | 1 | |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.165 | 0.1423 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Brugia malayi | Hint module family protein | 0.0161 | 0.165 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.165 | 0.1423 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.037 | 0.4425 | 0.4273 |
Echinococcus multilocularis | smoothened | 0.0692 | 0.8697 | 1 |
Schistosoma mansoni | lozenge | 0.0057 | 0.0265 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 0.8507 | 0.8466 |
Schistosoma mansoni | hypothetical protein | 0.0431 | 0.5243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.5502 | 0.538 |
Brugia malayi | Hint module family protein | 0.0161 | 0.165 | 0.165 |
Echinococcus multilocularis | Protein lozenge | 0.0057 | 0.0265 | 0.0304 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.037 | 0.4425 | 0.5088 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.5502 | 0.538 |
Brugia malayi | hypothetical protein | 0.0451 | 0.5502 | 0.5502 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | Desert hedgehog protein | 0.0592 | 0.738 | 0.8486 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.4873 | 0.4734 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.037 | 0.4425 | 0.5088 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.037 | 0.4425 | 0.4425 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | hedgehog | 0.0592 | 0.738 | 0.8486 |
Loa Loa (eye worm) | hypothetical protein | 0.079 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.037 | 0.4425 | 0.8439 |
Leishmania major | C-8 sterol isomerase-like protein | 0.079 | 1 | 1 |
Echinococcus granulosus | smoothened | 0.0692 | 0.8697 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 107 % | Ability to open cloned mKCNQ2 channel expressed in Xenopus laevis oocytes at 10 uM expressed as percent of compound-free control current at -40 mV | ChEMBL. | 15139767 |
Control (functional) | = 107 % | Ability to open cloned mKCNQ2 channel expressed in Xenopus laevis oocytes at 10 uM expressed as percent of compound-free control current at -40 mV | ChEMBL. | 15139767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.