Detailed information for compound 1618383

Basic information

Technical information
  • TDR Targets ID: 1618383
  • Name: (2S,5'R)-7-chloro-6-hydroxy-3',4-dimethoxy-5' -methylspiro[1-benzofuran-2,4'-cyclohex-2-ene ]-1',3-dione
  • MW: 338.74 | Formula: C16H15ClO6
  • H donors: 1 H acceptors: 3 LogP: 2.07 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(=O)C[C@H]([C@@]21Oc1c(C2=O)c(OC)cc(c1Cl)O)C
  • InChi: 1S/C16H15ClO6/c1-7-4-8(18)5-11(22-3)16(7)15(20)12-10(21-2)6-9(19)13(17)14(12)23-16/h5-7,19H,4H2,1-3H3/t7-,16+/m1/s1
  • InChiKey: SYNGDIBHUPXIQA-QZTNRIJFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,5'R)-7-chloro-6-hydroxy-3',4-dimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
  • (2S,5'R)-7-chloro-6-hydroxy-3',4-dimethoxy-5'-methylspiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
  • (2S,5'R)-7-chloro-6-hydroxy-3',4-dimethoxy-5'-methyl-spiro[benzofuran-2,4'-cyclohex-2-ene]-1',3-quinone
  • (2S,5'R)-7-chloro-6-hydroxy-3',4-dimethoxy-5'-methyl-spiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0165 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0145 0.0113
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0145 0.0757
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0102 0.0198 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0249 0.0643 0.1334
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Loa Loa (eye worm) hypothetical protein 0.0249 0.0643 0.0613
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0165 0.1672
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0165 0.3397
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Mycobacterium ulcerans hypothetical protein 0.0163 0.0384 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0165 0.0134
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0333 0.3871
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0249 0.0643 0.0643
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0249 0.0643 0.3359
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 0.7702
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0249 0.0643 0.7702
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.3082 0.9245 0.9242
Loa Loa (eye worm) hypothetical protein 0.0153 0.0353 0.0322
Echinococcus granulosus neuropeptide receptor 0.0436 0.1213 0.6336
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0249 0.0643 0.3359
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0249 0.0643 0.0643
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0049 0.0358
Chlamydia trachomatis cytosol aminopeptidase 0.0102 0.0198 0.5
Loa Loa (eye worm) hypothetical protein 0.3082 0.9245 0.9242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Schistosoma mansoni patched 1 0.0085 0.0145 0.0145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0249 0.0643 0.3359
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Plasmodium falciparum phosphodiesterase gamma, putative 0.0249 0.0643 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0165 0.1794
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0249 0.0643 0.3359
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0249 0.0643 0.0643
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0249 0.0643 0.7702
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0643 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.0829 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0249 0.0643 0.0643
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0249 0.0643 1
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0249 0.0643 0.0613
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0102 0.0198 0.2196
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0249 0.0643 0.1334
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0249 0.0643 0.1334
Trypanosoma brucei polo-like protein kinase 0.0091 0.0165 0.1794
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0145 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0145 0.1936
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0249 0.0643 0.1334
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.1914 0.1914
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.0829 1
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0353 0.0733
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0249 0.0643 0.7702
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0496 0.0496
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0102 0.0198 0.2196
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Giardia lamblia hypothetical protein 0.0249 0.0643 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Brugia malayi Muscleblind-like protein 0.0153 0.0353 0.0353
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus granulosus muscleblind protein 0.0153 0.0353 0.1846
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0249 0.0643 0.0643
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0353 0.0322
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0032 0.0032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus granulosus microtubule associated protein 2 0.0668 0.1914 1
Echinococcus granulosus expressed conserved protein 0.0185 0.045 0.2352
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0333 0.3871
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0203 0.0171
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0165 0.0165
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0145 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Leishmania major mitochondrial DNA polymerase beta 0.031 0.0829 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0249 0.0643 0.3359
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0165 0.0165
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0249 0.0643 0.1334
Echinococcus multilocularis protein dispatched 1 0.0097 0.0181 0.0376
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0249 0.0643 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0249 0.0643 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0032 0.0659
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.0744 0.3884
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0165 0.1794
Echinococcus multilocularis expressed conserved protein 0.0185 0.045 0.0934
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0249 0.0643 0.1334
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0333 0.378
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0102 0.0198 0.208
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Leishmania major hypothetical protein, conserved 0.0249 0.0643 0.7668
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0249 0.0643 0.1334
Loa Loa (eye worm) hypothetical protein 0.0197 0.0487 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0643 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0384 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0102 0.0198 0.262
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0249 0.0643 0.7702
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Echinococcus multilocularis neuropeptide receptor 0.0436 0.1213 0.2517
Schistosoma mansoni neuropeptide receptor 0.0436 0.1213 0.1213
Echinococcus multilocularis protein patched 0.0085 0.0145 0.0301
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0102 0.0198 0.2196
Echinococcus multilocularis leucine aminopeptidase protein 0.0102 0.0198 0.041
Leishmania major cAMP-specific phosphodiesterase, putative 0.0249 0.0643 0.7668
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0249 0.0643 0.1334
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.0829 1
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0102 0.0198 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0145 0.0757
Loa Loa (eye worm) hypothetical protein 0.0249 0.0643 0.0613
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0102 0.0198 0.4715
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 0.7702
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis G protein coupled receptor 139 0.0436 0.1213 0.2517
Trypanosoma brucei hypothetical protein, conserved 0.0249 0.0643 0.7702
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.0487 0.101
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0165 0.0863
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0032 0.0659
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0249 0.0643 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0249 0.0643 0.7702
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0249 0.0643 0.7668
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0249 0.0643 0.3359
Trichomonas vaginalis conserved hypothetical protein 0.0249 0.0643 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0249 0.0643 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Giardia lamblia Hypothetical protein 0.0249 0.0643 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0032 0.0032
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.0744 0.1543
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Echinococcus granulosus leucine aminopeptidase protein 0.0102 0.0198 0.1033
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0249 0.0643 0.3359
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Leishmania major hypothetical protein, conserved 0.0249 0.0643 0.7668
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0032 0.0659
Brugia malayi CHE-14 protein 0.0085 0.0145 0.0145
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0165 0.0343
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.1914 0.3972
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0249 0.0643 0.0643
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0165 0.2267
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1625 0.482 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0249 0.0643 0.0643
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0249 0.0643 0.3359
Schistosoma mansoni hypothetical protein 0.0082 0.0136 0.0136
Echinococcus multilocularis muscleblind protein 0.0153 0.0353 0.0733
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0249 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.3082 0.9245 0.9242
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Mycobacterium ulcerans leucyl aminopeptidase 0.0102 0.0198 0.4715
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.0487 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0249 0.0643 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.0487 0.0487
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0249 0.0643 0.0643
Loa Loa (eye worm) PDE1B protein 0.0249 0.0643 0.0613
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0249 0.0643 0.7702
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.0487 0.2542
Trypanosoma cruzi hypothetical protein, conserved 0.0249 0.0643 0.7702
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0032 0.0032
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0249 0.0643 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0249 0.0643 1
Schistosoma mansoni kinase 0.0046 0.0029 0.0029
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0249 0.0643 0.7702

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) < 50 % Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 50 uM after 48 hrs by MTT assay ChEMBL. 22191585

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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