Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | d-amino acid oxidase | 0.0521 | 1 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0521 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0477 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0521 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative EC30 (functional) | = 0.29 nM | Relative transcriptional activation in COS cells expressing Retinoic acid receptor alpha compared to ATRA | ChEMBL. | 10956201 |
Relative EC30 (functional) | = 0.29 nM | Relative transcriptional activation in COS cells expressing Retinoic acid receptor alpha compared to ATRA | ChEMBL. | 10956201 |
Relative EC30 (functional) | = 8.5 nM | Relative transcriptional activation in COS cells expressing Retinoic acid receptor beta compared to ATRA | ChEMBL. | 10956201 |
Relative EC30 (functional) | = 8.5 nM | Relative transcriptional activation in COS cells expressing Retinoic acid receptor beta compared to ATRA | ChEMBL. | 10956201 |
Relative EC30 (functional) | = 110 nM | Relative transcriptional activation in COS cells expressing Retinoic acid receptor gamma compared to ATRA | ChEMBL. | 10956201 |
Relative EC30 (functional) | = 110 nM | Relative transcriptional activation in COS cells expressing Retinoic acid receptor gamma compared to ATRA | ChEMBL. | 10956201 |
Relative IC50 (binding) | 0 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor gamma; ND means not detectable (because relative IC50>1000) | ChEMBL. | 10956201 |
Relative IC50 (functional) | = 0.37 nM | Inhibition of LPS-induced mouse B-lymphocyte proliferation (Mean of IC50/ATRA IC50) | ChEMBL. | 10956201 |
Relative IC50 (binding) | = 1.9 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor alpha (RAR-alpha) | ChEMBL. | 10956201 |
Relative IC50 (binding) | = 1.9 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor alpha (RAR-alpha) | ChEMBL. | 10956201 |
Relative IC50 (binding) | = 500 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor beta (RAR-beta) | ChEMBL. | 10956201 |
Relative IC50 (binding) | = 500 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor beta (RAR-beta) | ChEMBL. | 10956201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.