Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative regulatory protein | 0.0044 | 0.0125 | 0.4808 |
Echinococcus granulosus | single minded 2 | 0.0044 | 0.0125 | 0.0128 |
Brugia malayi | PAS domain containing protein | 0.006 | 0.026 | 0.359 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0259 | 0.0266 |
Leishmania major | protein kinase, putative | 0.0045 | 0.0135 | 0.0135 |
Brugia malayi | bHLH-PAS transcription factor | 0.0044 | 0.0125 | 0.1721 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0259 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0045 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0128 | 0.086 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0259 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0729 | 0.8478 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0045 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0047 | 0.0047 |
Onchocerca volvulus | 0.0045 | 0.0129 | 0.1502 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0259 | 0.0259 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0047 | 0.0047 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0047 | 0.0047 |
Trypanosoma cruzi | protein kinase, putative | 0.1142 | 0.9739 | 0.9739 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0047 | 0.0047 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0045 | 0.0135 | 0.0135 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0047 | 0.0049 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0045 | 0.0135 | 0.0135 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0259 | 0.0259 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0259 | 0.0259 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0044 | 0.0125 | 0.0128 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0047 | 0.0047 |
Echinococcus multilocularis | serine:threonine protein kinase Nek1 | 0.1142 | 0.9739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0725 | 0.8425 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0259 | 0.0259 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0047 | 0.0653 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0259 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0047 | 0.0049 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0129 | 0.0865 | 0.0888 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0259 | 0.0266 |
Leishmania major | protein kinase, putative | 0.0045 | 0.0135 | 0.0135 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0047 | 0.0047 |
Schistosoma mansoni | single-minded | 0.006 | 0.026 | 0.026 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0259 | 1 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0113 | 0.0725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.086 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Nek1 | 0.1142 | 0.9739 | 1 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0129 | 0.0865 | 0.0888 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0173 | 0.1251 | 0.1251 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.793 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.419 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.759 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.751 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.721 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.716 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.712 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.672 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.665 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.653 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.