Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0305 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0305 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0305 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0305 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0305 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0305 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0305 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0305 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0305 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0305 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 281 ug min ml-1 | AUC in dog after oral dose (1 mg/kg) | ChEMBL. | 12270176 |
Cmax (ADMET) | = 0.64 ug ml-1 | Cmax in dog plasma after oral dose (1 mg/kg) | ChEMBL. | 12270176 |
Ki (binding) | = 17.6 ug nM-1 | In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate | ChEMBL. | 12270176 |
Ki (binding) | = 17.6 ug nM-1 | In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate | ChEMBL. | 12270176 |
pKa | = 8.6 | Ionisation constant (pKa) | ChEMBL. | 12270176 |
T1/2 (ADMET) | = 261 min | t1/2 in dog after oral dose (1 mg/kg) | ChEMBL. | 12270176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.