Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.0159 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0126 | 0.7176 | 0.7005 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0119 | 0.6562 | 0.6354 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0051 | 0.0614 | 1 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0126 | 0.7176 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0126 | 0.7176 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0051 | 0.0571 | 0.0145 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0126 | 0.7176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.7176 | 0.7005 |
Schistosoma mansoni | tyrosine kinase | 0.0085 | 0.3588 | 0.32 |
Echinococcus multilocularis | insulin receptor | 0.0051 | 0.0571 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.351 | 0.3117 |
Brugia malayi | kinase, mitochondrial precursor | 0.0126 | 0.7176 | 0.7005 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0126 | 0.7176 | 0.7048 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0126 | 0.7176 | 0.7005 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0085 | 0.3588 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0085 | 0.3588 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0085 | 0.3588 | 0.32 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0126 | 0.7176 | 0.7048 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.351 | 0.3117 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0085 | 0.3588 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0159 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0159 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0119 | 0.6562 | 0.6354 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.351 | 0.3117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.