Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate dehydrogenase | 0.0119 | 0.6562 | 0.6354 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0159 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0051 | 0.0571 | 0.0145 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0126 | 0.7176 | 0.7048 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.7176 | 0.7005 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.351 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0085 | 0.3588 | 0.32 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0126 | 0.7176 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0051 | 0.0571 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0085 | 0.3588 | 0.32 |
Brugia malayi | kinase, mitochondrial precursor | 0.0126 | 0.7176 | 0.7005 |
Schistosoma mansoni | tyrosine kinase | 0.0085 | 0.3588 | 0.32 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0119 | 0.6562 | 0.6354 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0126 | 0.7176 | 0.7048 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0085 | 0.3588 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.351 | 0.3117 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0126 | 0.7176 | 0.7005 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0126 | 0.7176 | 0.7005 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0159 | 1 | 1 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0126 | 0.7176 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0126 | 0.7176 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0085 | 0.3588 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0051 | 0.0614 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.351 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0159 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.