Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.273 | 1 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.273 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0919 | 0.2148 | 0.1706 |
Echinococcus granulosus | histone deacetylase 6 | 0.2439 | 0.8738 | 0.8667 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.1164 | 0.321 | 0.321 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1711 | 0.5581 | 0.5332 |
Echinococcus multilocularis | histone deacetylase 6 | 0.2439 | 0.8738 | 0.8678 |
Schistosoma mansoni | tyrosine kinase | 0.091 | 0.2106 | 0.1662 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.273 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.273 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0547 | 0.0533 | 0.0078 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0919 | 0.2148 | 0.1706 |
Echinococcus multilocularis | histone deacetylase 6 | 0.2419 | 0.865 | 0.8585 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.1164 | 0.321 | 0.2828 |
Trypanosoma brucei | histone deacetylase 4 | 0.2419 | 0.865 | 0.8011 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.273 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.2419 | 0.865 | 0.8011 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.273 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.1164 | 0.321 | 0.321 |
Echinococcus granulosus | histone deacetylase 7 | 0.2419 | 0.865 | 0.8573 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.273 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.1164 | 0.321 | 0.2884 |
Trypanosoma cruzi | histone deacetylase, putative | 0.2419 | 0.865 | 0.8011 |
Echinococcus multilocularis | histone deacetylase 6 | 0.2419 | 0.865 | 0.8585 |
Loa Loa (eye worm) | hypothetical protein | 0.1164 | 0.321 | 0.2828 |
Echinococcus multilocularis | histone deacetylase 3 | 0.273 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.2419 | 0.865 | 0.8573 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.273 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0919 | 0.2148 | 0.1706 |
Leishmania major | histone deacetylase, putative | 0.273 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1711 | 0.5581 | 0.5332 |
Trypanosoma cruzi | histone deacetylase, putative | 0.2419 | 0.865 | 0.8011 |
Loa Loa (eye worm) | hypothetical protein | 0.273 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.273 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0547 | 0.0533 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.1254 | 0.3602 | 0.3241 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1711 | 0.5581 | 0.5332 |
Echinococcus granulosus | histone deacetylase 6 | 0.2419 | 0.865 | 0.8573 |
Echinococcus multilocularis | histone deacetylase | 0.2419 | 0.865 | 0.8585 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.273 | 1 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.1164 | 0.321 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.2419 | 0.865 | 0.8011 |
Trichomonas vaginalis | histone deacetylase, putative | 0.273 | 1 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.2419 | 0.865 | 0.8585 |
Leishmania major | histone deacetylase, putative | 0.273 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.273 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.2419 | 0.865 | 0.865 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.1164 | 0.321 | 0.2828 |
Plasmodium vivax | histone deacetylase, putative | 0.2419 | 0.865 | 0.8011 |
Schistosoma mansoni | histone deacetylase hda2 | 0.2439 | 0.8738 | 0.8667 |
Schistosoma mansoni | tyrosine kinase | 0.091 | 0.2106 | 0.1662 |
Schistosoma mansoni | tyrosine kinase | 0.0919 | 0.2148 | 0.1706 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.2419 | 0.865 | 0.8573 |
Schistosoma mansoni | histone deacetylase hda2 | 0.1164 | 0.321 | 0.2828 |
Plasmodium vivax | histone deacetylase 1, putative | 0.273 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.2419 | 0.865 | 0.8011 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.273 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.091 | 0.2106 | 0.1662 |
Trypanosoma brucei | histone deacetylase 1 | 0.273 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.273 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1275 | 0.3691 | 0.3335 |
Echinococcus granulosus | histone deacetylase 6 | 0.2419 | 0.865 | 0.8573 |
Brugia malayi | Histone deacetylase family protein | 0.2419 | 0.865 | 0.8573 |
Schistosoma mansoni | histone deacetylase | 0.273 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.2419 | 0.865 | 0.8573 |
Echinococcus granulosus | histone deacetylase 3 | 0.273 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.273 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.2419 | 0.865 | 0.8011 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.2419 | 0.865 | 0.8573 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0919 | 0.2148 | 0.1771 |
Brugia malayi | histone deacetylase 11 | 0.1164 | 0.321 | 0.2828 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1711 | 0.5581 | 0.5368 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.273 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.1164 | 0.321 | 0.2828 |
Echinococcus multilocularis | histone deacetylase 1 | 0.273 | 1 | 1 |
Echinococcus granulosus | histone deacetylase | 0.2419 | 0.865 | 0.8573 |
Entamoeba histolytica | histone deacetylase, putative | 0.273 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1711 | 0.5581 | 0.5332 |
Echinococcus granulosus | histone deacetylase 1 | 0.273 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.273 | 1 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.273 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.2419 | 0.865 | 0.8573 |
Schistosoma mansoni | histone deacetylase | 0.273 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.273 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.563 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.188 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.079 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.926 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.899 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.835 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.805 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.776 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.