Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase family protein | 0.0079 | 0.8692 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0079 | 0.8692 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0079 | 0.8692 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0079 | 0.8692 | 0.8203 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0079 | 0.8692 | 0.8203 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0086 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0079 | 0.8692 | 0.8203 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.005 | 0.2723 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0079 | 0.8692 | 0.8203 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2723 | 0.3133 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0079 | 0.8692 | 0.8203 |
Trichomonas vaginalis | histone deacetylase, putative | 0.005 | 0.2723 | 0.5 |
Plasmodium falciparum | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.005 | 0.2723 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.005 | 0.2723 | 0.3133 |
Entamoeba histolytica | histone deacetylase, putative | 0.005 | 0.2723 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.0079 | 0.8692 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.005 | 0.2723 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0079 | 0.8692 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.005 | 0.2723 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0079 | 0.8692 | 0.8203 |
Trichomonas vaginalis | histone deacetylase, putative | 0.005 | 0.2723 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0079 | 0.8692 | 0.8203 |
Echinococcus granulosus | histone deacetylase | 0.0079 | 0.8692 | 0.8203 |
Plasmodium falciparum | histone deacetylase 2 | 0.0079 | 0.8692 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.005 | 0.2723 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0086 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0079 | 0.8692 | 0.8203 |
Trichomonas vaginalis | histone deacetylase, putative | 0.005 | 0.2723 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2723 | 0.3133 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0079 | 0.8692 | 1 |
Leishmania major | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.005 | 0.2723 | 0.3133 |
Trypanosoma brucei | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0079 | 0.8692 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0079 | 0.8692 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.005 | 0.2723 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.005 | 0.2723 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0079 | 0.8692 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0079 | 0.8692 | 0.8203 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.005 | 0.2723 | 0.3133 |
Giardia lamblia | Histone deacetylase | 0.005 | 0.2723 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 500 uM | Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry | ChEMBL. | 22386984 |
IC50 (binding) | > 500 uM | Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry | ChEMBL. | 22386984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.