Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0253 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0099 | 0.0588 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.1687 | 0.043 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.1687 | 0.043 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0095 | 0.2441 | 1 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.1687 | 0.043 |
Echinococcus granulosus | sodium calcium exchanger | 0.0237 | 0.8991 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.1359 | 0.5377 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.1687 | 0.043 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.1687 | 0.043 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.1359 | 0.1416 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.1687 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.1359 | 0.1416 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.1687 | 1 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.1359 | 0.5377 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.1687 | 0.043 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0237 | 0.8991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2441 | 0.2634 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0253 | 0.15 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.1359 | 0.1416 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0237 | 0.8991 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.1687 | 0.1785 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0099 | 0.0588 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.1687 | 0.6777 |
Brugia malayi | RNA binding protein | 0.0071 | 0.1359 | 0.5377 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0253 | 0.15 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0237 | 0.8991 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.228 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.