Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.7741 | 0.7741 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0022 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0022 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.7741 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0022 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0022 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.7741 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0022 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0022 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.7741 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0022 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0022 | 1 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0022 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.7741 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0022 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0022 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0022 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0022 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Schistosoma mansoni | brg-1 associated factor | 0.0022 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0022 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0022 | 1 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.7741 | 0.7741 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0022 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.7741 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.7741 | 0.7741 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0022 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0022 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.7741 | 1 |
Onchocerca volvulus | 0.0022 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3109 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.