Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aurora kinase A | 0.0117 | 0.0552 | 0.0552 |
Echinococcus granulosus | aurora kinase A | 0.0117 | 0.0552 | 0.0552 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.1041 | 0.8961 | 0.8961 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0058 | 0.0014 | 0.0014 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1155 | 1 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.1155 | 1 | 1 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.1041 | 0.8961 | 0.8961 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.1155 | 1 | 1 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.1155 | 1 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1155 | 1 | 1 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.1155 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0552 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0117 | 0.0552 | 0.0284 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0117 | 0.0552 | 0.0538 |
Giardia lamblia | Aurora kinase | 0.0117 | 0.0552 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0117 | 0.0552 | 1 |
Schistosoma mansoni | protein kinase | 0.0117 | 0.0552 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.1155 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0058 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | AUR protein kinase | 0.0117 | 0.0552 | 0.0284 |
Brugia malayi | serine/threonine kinase 12 | 0.0117 | 0.0552 | 0.0284 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0117 | 0.0552 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0117 | 0.0552 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1155 | 1 | 1 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0114 | 0.0526 | 0.0512 |
Entamoeba histolytica | protein kinase, putative | 0.0117 | 0.0552 | 1 |
Toxoplasma gondii | aurora kinase | 0.0117 | 0.0552 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0087 | 0.0276 | 0.4871 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1155 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0552 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.1155 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0117 | 0.0552 | 0.0284 |
Entamoeba histolytica | protein kinase , putative | 0.0117 | 0.0552 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0117 | 0.0552 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1155 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0117 | 0.0552 | 0.0552 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0117 | 0.0552 | 0.0552 |
Entamoeba histolytica | protein kinase, putative | 0.0087 | 0.0276 | 0.4871 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0552 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0117 | 0.0552 | 0.0538 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0117 | 0.0552 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0058 | 0.0014 | 0.0014 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0117 | 0.0552 | 0.0284 |
Entamoeba histolytica | protein kinase, putative | 0.0087 | 0.0276 | 0.4871 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1155 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0117 | 0.0552 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0058 | 0.0014 | 0.0014 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.1155 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0117 | 0.0552 | 0.0284 |
Loa Loa (eye worm) | AUR protein kinase | 0.0117 | 0.0552 | 0.0284 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1155 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0117 | 0.0552 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0117 | 0.0552 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0058 | 0.0014 | 0.0014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.592 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.139 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.983 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.901 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.81 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.535 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.274 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.